64820-99-1
Chemical Structure
Vitexin-2"-O-rhamnoside
- CAS No.: 64820-99-1
- Formula:C27H30O14
- Molecular Weight:578.52
IUPAC Name: 8-((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
InChIKey: LYGPBZVKGHHTIE-HUBYJIGHSA-N
SMILES: OC1=CC(O)=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=C1[C@H](O[C@H](CO)[C@@H](O)[C@@H]4O)[C@@H]4O[C@@](O[C@@H](C)[C@H](O)[C@H]5O)([H])[C@@H]5O
Biological Activity: Vitexin-2"-O-rhamnoside is an orally active flavonoid glycoside. Vitexin-2"-O-rhamnoside inhibits Apoptosis, increases the phosphorylation levels of PI3K/Akt, inhibits caspase-3, SOD activity, and promotes cytokine (IL-2, IL-6, and IL-12) secretion. Vitexin-2"-O-rhamnoside strongly inhibits DNA synthesis in MCF-7 cells with an IC50 of 17.5 μM. Vitexin-2"-O-rhamnoside enhances immune function and improves the absorption of active compounds. Vitexin-2"-O-rhamnoside has antioxidant activity. Vitexin-2"-O-rhamnoside is used in the study of cardiovascular disease and immune-related diseases[1][2][3][4][5][6].
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Vitexin-2"-O-rhamnoside | 99.78% | Vitexin-2"-O-rhamnoside is an orally active flavonoid glycoside. Vitexin-2"-O-rhamnoside inhibits Apoptosis, increases the phosphorylation levels of PI3K/Akt, inhibits caspase-3, SOD activity, and promotes cytokine (IL-2, IL-6, and IL-12) secretion. Vitexin-2"-O-rhamnoside strongly inhibits DNA synthesis in MCF-7 cells with an IC50 of 17.5 μM. Vitexin-2"-O-rhamnoside enhances immune function and improves the absorption of active compounds. Vitexin-2"-O-rhamnoside has antioxidant activity. Vitexin-2"-O-rhamnoside is used in the study of cardiovascular disease and immune-related diseases. | ||||||||||||||||||||
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Vitexin-2"-O-rhamnoside (Standard) | ≥98% | Vitexin-2"-O-rhamnoside (Standard) is the analytical standard of Vitexin-2"-O-rhamnoside (HY-N0534). This product is intended for research and analytical applications. Vitexin-2"-O-rhamnoside is an orally active flavonoid glycoside. Vitexin-2"-O-rhamnoside inhibits Apoptosis, increases the phosphorylation levels of PI3K/Akt, inhibits caspase-3, SOD activity, and promotes cytokine (IL-2, IL-6, and IL-12) secretion. Vitexin-2"-O-rhamnoside strongly inhibits DNA synthesis in MCF-7 cells with an IC50 of 17.5 μM. Vitexin-2"-O-rhamnoside enhances immune function and improves the absorption of active compounds. Vitexin-2"-O-rhamnoside has antioxidant activity. Vitexin-2"-O-rhamnoside is used in the study of cardiovascular disease and immune-related diseases. | ||||||||||||||||||||
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- [1]. Wei W, et al. Effects of vitexin-2"-O-rhamnoside and vitexin-4"-O-glucoside on growth and oxidative stress-induced cell apoptosis of human adipose-derived stem cells. J Pharm Pharmacol. 2014 Jul;66(7):988-97. [Content Brief]
- [2]. Ying X, et al. LC determination of malondialdehyde concentrations in the human umbilical vein endothelial cell culture medium: application to the antioxidant effect of Vitexin-2 ″-O-rhamnoside. Chromatographia, 2008, 67: 679-686.
- [3]. Cai S, et al. Comparative study on the excretion of vitexin-4''-O-glucoside in mice after oral and intravenous administration by using HPLC. Biomed Chromatogr. 2013 Nov;27(11):1375-9. [Content Brief]
- [4]. Wang Y, et al. Vitexin-2-O-rhamnoside improves immunosuppression, oxidative stress, and phosphorylation of PI3K/Akt signal pathway in cyclophosphamide treated mice. Eur J Pharmacol. 2022 Jun 15;925:174999. [Content Brief]
- [5]. Lu D, et al. Bioavailability of vitexin-2”-O-rhamnoside after oral co-administration with ketoconazole, verapamil and bile salts. Latin Am J Pharm, 2013, 32: 1218-23.
- [6]. Ninfali P, et al. Characterization and biological activity of the main flavonoids from Swiss Chard (Beta vulgaris subspecies cycla). Phytomedicine. 2007 Feb;14(2-3):216-21. [Content Brief]
