6964-20-1
Chemical Structure
Tiadenol
- CAS No.: 6964-20-1
- Formula:C14H30O2S2
- Molecular Weight:294.52
IUPAC Name: 2,2'-(decane-1,10-diylbis(sulfanediyl))bis(ethan-1-ol)
InChIKey: WRCITXQNXAIKLR-UHFFFAOYSA-N
SMILES: OCCSCCCCCCCCCCSCCO
Biological Activity: Tiadenol is an orally effective lipid-lowering compound and peroxisome proliferator. Tiadenol promotes peroxisome-associated fatty acid metabolism, and its induction of the activities of enzymes such as palmitoyl-CoA hydrolase, carnitine acetyl-transferase and catalase is mainly associated with de novo protein synthesis. The triglyceride-lowering effect of Tiadenol is not accompanied by increased activities of lipoprotein lipase (LPL) and hepatic lipase (HL), and it reduces VLDL Apo E. Tiadenol can be used in studies related to lipid metabolism, peroxisome proliferation and hyperlipoproteinemia[1][2][3][4].
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Tiadenol | Tiadenol is an orally effective lipid-lowering compound and peroxisome proliferator. Tiadenol promotes peroxisome-associated fatty acid metabolism, and its induction of the activities of enzymes such as palmitoyl-CoA hydrolase, carnitine acetyl-transferase and catalase is mainly associated with de novo protein synthesis. The triglyceride-lowering effect of Tiadenol is not accompanied by increased activities of lipoprotein lipase (LPL) and hepatic lipase (HL), and it reduces VLDL Apo E. Tiadenol can be used in studies related to lipid metabolism, peroxisome proliferation and hyperlipoproteinemia. | |||||||||||||||||||||
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References
- [1]. Rozé C, et al. The effects of tiadenol, clofibrate and clofibride on bile composition in the rat. European journal of pharmacology. 1977 May 01;43(1):57-64. [Content Brief]
- [2]. Franceschini G, et al. Pharmacological studies on tiadenol in type IV patients: Evidence for a mechanism of action different from other lipid-lowering drugs. Atherosclerosis. 1981;40:245-255. [Content Brief]
- [3]. Bakke OM, et al. Lipid-metabolizing enzymes, CoASH and long-chain acyl-CoA in rat liver after treatment with tiadenol, nicotinic acid and niadenate. Biochem Pharmacol. 1982;31(23):3930-3933.
- [4]. Berge RK, et al. Tiadenol-mediated induction of peroxisomal enzymes in cultured C3H/10T1/2 CL8 cells and in chemically transformed C3H/10T1/2 MCA16 cells. Int J Cancer. 1985;36:489-494. [Content Brief]
