710972-61-5
710972-61-5
Chemical Structure
EGFR/VEGFR2-IN-3
- CAS No.: 710972-61-5
- Formula:C24H20ClN5O2S2
- Molecular Weight:510.03
SMILES: CC1=CC=C(C=C1)NC(NNC(CSC2=NC3=CC=CC=C3C(N2C4=CC=C(C=C4)Cl)=O)=O)=S
Biological Activity: EGFR/VEGFR2-IN-3 (compound 9) is a potent EGFR and VEGFR-2 inhibitor with IC50 values of 0.129, 0.142, 3.428 µM for EGFR, VEGFR-2, COX-2, respectively. EGFR/VEGFR2-IN-3 shows cytotoxicity. EGFR/VEGFR2-IN-3 induces apoptosis and cell cycle arrest at G2/M phase[1].
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EGFR/VEGFR2-IN-3 | EGFR/VEGFR2-IN-3 (compound 9) is a potent EGFR and VEGFR-2 inhibitor with IC50 values of 0.129, 0.142, 3.428 µM for EGFR, VEGFR-2, COX-2, respectively. EGFR/VEGFR2-IN-3 shows cytotoxicity. EGFR/VEGFR2-IN-3 induces apoptosis and cell cycle arrest at G2/M phase. | |||||||||||||||||||||
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Keywords
