722543-50-2
Chemical Structure
Barasertib dihydrochloride
Synonym(s): AZD1152 dihydrochloride
- CAS No.: 722543-50-2
- Formula:C26H33Cl2FN7O6P
- Molecular Weight:660.46
IUPAC Name: 2-(ethyl(3-((4-((3-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1H-pyrazol-5-yl)amino)quinazolin-7-yl)oxy)propyl)amino)ethyl dihydrogen phosphate dihydrochloride
InChIKey: PEVRMFUIHQMEHQ-UHFFFAOYSA-N
SMILES: O=C(CC1=NNC(NC2=C3C=CC(OCCCN(CCOP(O)(O)=O)CC)=CC3=NC=N2)=C1)NC4=CC(F)=CC=C4.Cl.Cl
Biological Activity: Barasertib (AZD1152 dihydrochloride), a pro-drug of Barasertib-hQPA, is a highly selective Aurora B inhibitor with an IC50 of 0.37 nM in a cell-free assay. Barasertib (AZD1152 dihydrochloride) induces growth arrest and apoptosis in cancer cells[1].
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Barasertib dihydrochloride | Barasertib (AZD1152 dihydrochloride), a pro-drug of Barasertib-hQPA, is a highly selective Aurora B inhibitor with an IC50 of 0.37 nM in a cell-free assay. Barasertib (AZD1152 dihydrochloride) induces growth arrest and apoptosis in cancer cells. | |||||||||||||||||||||
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