76990-85-7
Chemical Structure
Milacemide hydrochloride
Synonym(s): CP 1552 S
- CAS No.: 76990-85-7
- Formula:C7H17ClN2O
- Molecular Weight:180.68
IUPAC Name: 2-(pentylamino)acetamide hydrochloride
InChIKey: DNSCECUSJKDSKP-UHFFFAOYSA-N
SMILES: O=C(N)CNCCCCC.Cl
Biological Activity: Milacemide hydrochloride (CP 1552 S), a glycinamide derivative, is an orally active MAO-B inhibitor with anticonvulsant activity. Milacemide hydrochloride reduces the levels of dihydroxyphenylacetic acid and homovanilic acid, but increases the levels of dopamine and serotonin in the caudate nucleus. Milacemide hydrochloride is promising for research of Alzheimer's disease[1][2].
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Milacemide hydrochloride | Milacemide hydrochloride (CP 1552 S), a glycinamide derivative, is an orally active MAO-B inhibitor with anticonvulsant activity. Milacemide hydrochloride reduces the levels of dihydroxyphenylacetic acid and homovanilic acid, but increases the levels of dopamine and serotonin in the caudate nucleus. Milacemide hydrochloride is promising for research of Alzheimer's disease. | |||||||||||||||||||||
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- [1]. Janssens de Varebeke P, et al. Milacemide, the selective substrate and enzyme-activated specific inhibitor of monoamine oxidase B, increases dopamine but not serotonin in caudate nucleus of rhesus monkey. Neurochem Int. 1990;17(2):325-9. [Content Brief]
- [2]. Colombo M, et al. MAO activity, metabolism and anticonvulsant activity of milacemide in rats and mice. J Neural Transm Suppl. 1990;32:123-9. [Content Brief]
Keywords
