78541-97-6
78541-97-6
Chemical Structure
Piquindone
Synonym(s): Ro 22-1319
- CAS No.: 78541-97-6
- Formula:C15H22N2O
- Molecular Weight:246.35
IUPAC Name: (4aS,8aS)-3-ethyl-2,6-dimethyl-1,4a,5,6,7,8,8a,9-octahydro-4H-pyrrolo[2,3-g]isoquinolin-4-one
InChIKey: PVZMYDPRVUCJKV-CMPLNLGQSA-N
SMILES: CCC1=C(C)NC(C[C@@]2([H])[C@@]3([H])CN(C)CC2)=C1C3=O
Biological Activity: Piquindone (Ro 22-1319) is a potent antipsychotic agent. Piquindone binds to a D2 dopaminergic receptor subtype in a sodium-dependent manner. Piquindone can be used in the research of schizophrenia[1][2].
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Piquindone | Piquindone (Ro 22-1319) is a potent antipsychotic agent. Piquindone binds to a D2 dopaminergic receptor subtype in a sodium-dependent manner. Piquindone can be used in the research of schizophrenia. | |||||||||||||||||||||
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References
- [1]. Nakajima T, et al. [3H]Ro 22-1319 (piquindone) binds to the D2 dopaminergic receptor subtype in a sodium-dependent manner. Mol Pharmacol. 1984 Nov;26(3):430-8. [Content Brief]
- [2]. Cohen JD, et al. The efficacy of piquindone, a new atypical neuroleptic, in the treatment of the positive and negative symptoms of schizophrenia. J Clin Psychopharmacol. 1987 Oct;7(5):324-9. [Content Brief]
Keywords
