83601-81-4
Chemical Structure
Parbendazole hydrochloride
Synonym(s): SKF 29044 hydrochloride
- CAS No.: 83601-81-4
- Formula:C13H18ClN3O2
- Molecular Weight:283.75
InChIKey: KQIVUXJJSRFRFM-UHFFFAOYSA-N
SMILES: O=C(NC1=NC2=C(N1)C=CC(CCCC)=C2)OC.Cl
Biological Activity: Parbendazole hydrochloride (SKF‑29044 hydrochloride) is an orally active benzimidazole carbamate compound with multiple biological activities. Parbendazole hydrochloride binds to free tubulin and inhibits microtubule polymerization; it also activates the JNK/c‑Jun signaling axis and upregulates the expression of the downstream axonal repulsion factor Sema3A. Parbendazole hydrochloride upregulates KAL-1 mRNA expression, reduces nerve growth factor levels, and promotes the terminal differentiation of normal human epidermal keratinocytes. Parbendazole hydrochloride induces apoptosis in differentiated acute myeloid leukemia monocytes and exerts antileukemic activity in a mouse xenograft model of acute myeloid leukemia. Parbendazole hydrochloride exhibits broad-spectrum anthelmintic activity against various animal nematodes. Parbendazole hydrochloride is used in research related to acute myeloid leukemia and parasitic infections[1][2][3][4].
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Parbendazole hydrochloride | Parbendazole hydrochloride (SKF‑29044 hydrochloride) is an orally active benzimidazole carbamate compound with multiple biological activities. Parbendazole hydrochloride binds to free tubulin and inhibits microtubule polymerization; it also activates the JNK/c‑Jun signaling axis and upregulates the expression of the downstream axonal repulsion factor Sema3A. Parbendazole hydrochloride upregulates KAL-1 mRNA expression, reduces nerve growth factor levels, and promotes the terminal differentiation of normal human epidermal keratinocytes. Parbendazole hydrochloride induces apoptosis in differentiated acute myeloid leukemia monocytes and exerts antileukemic activity in a mouse xenograft model of acute myeloid leukemia. Parbendazole hydrochloride exhibits broad-spectrum anthelmintic activity against various animal nematodes. Parbendazole hydrochloride is used in research related to acute myeloid leukemia and parasitic infections. | |||||||||||||||||||||
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References
- [1]. Matsuo H, et al. Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes. Communications biology. 2024 Jan 24;7(1):123. [Content Brief]
- [2]. Fujita M, et al. Parbendazole induces semaphorin 3A expression via JNK/c-Jun signaling pathway in normal human epidermal keratinocytes. Journal of dermatological science. 2026 May;122(2):47-54.
- [3]. Foster KE, et al. A mutant beta-tubulin confers resistance to the action of benzimidazole-carbamate microtubule inhibitors both in vivo and in vitro. European journal of biochemistry. 1987 Mar 16;163(3):449-55. [Content Brief]
- [4]. Al‑Hadiya B M H. Chapter 5‑Parbendazole. In: Profiles of Drug Substances, Excipients and Related Methodology. Vol.35. 2010:263‑284.
