851688-13-6
Chemical Structure
IMTPPE
- CAS. Nr.: 851688-13-6
- Formula:C20H27N3O2S
- Molecular Weight:373.51
IUPAC Name: 2-(((3,5-dimethylisoxazol-4-yl)methyl)thio)-1-(4-(2,3-dimethylphenyl)piperazin-1-yl)ethan-1-one
InChIKey: UOYXGXJBTVISCR-UHFFFAOYSA-N
SMILES: O=C(CSCC1=C(ON=C1C)C)N2CCN(CC2)C3=CC=CC(C)=C3C
Biological Activity: IMTPPE is an inhibitor of the androgen receptor (AR) in C4-2 prostate cancer cells, inhibiting its transcriptional activity and protein levels. IMTPPE inhibited the proliferation of AR-positive prostate cancer cells but had no effect on AR-negative prostate cancer cells. IMTPPE also inhibited the growth of enzalutamide-resistant 22Rv1 xenograft tumors[1].
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IMTPPE | IMTPPE is an inhibitor of the androgen receptor (AR) in C4-2 prostate cancer cells, inhibiting its transcriptional activity and protein levels. IMTPPE inhibited the proliferation of AR-positive prostate cancer cells but had no effect on AR-negative prostate cancer cells. IMTPPE also inhibited the growth of enzalutamide-resistant 22Rv1 xenograft tumors. | |||||||||||||||||||||
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