870225-11-9
Chemical Structure
Tie2 kinase inhibitor 3
- CAS No.: 870225-11-9
- Formula:C29H30F4N8O2
- Molecular Weight:598.59
InChIKey: HHKGVQGXRGQBBA-UHFFFAOYSA-N
SMILES: O=C(C1=CC(OC2=C(C3=NC(NC)=NC=N3)C=CC=N2)=CC=C1F)NC4=CC(C(F)(F)F)=CC=C4N(CCCN(C)C)C
Biological Activity: Tie2 kinase inhibitor 3 (compound 63) is a potent Tie-2 kinase inhibitor with good oral activity (IC50=30 nM). Tie2 kinase inhibitor 3 inhibits phosphorylation and signaling of Tie-2 by competing with the ATP binding site of Tie-2 kinase. This inhibition affects the stability and maturity of blood vessels, which has an impact on tumor angiogenesis. Tie2 kinase inhibitor 3 can be used to restrict tumor growth and regulate angiogenesis[1].
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Tie2 kinase inhibitor 3 | Tie2 kinase inhibitor 3 (compound 63) is a potent Tie-2 kinase inhibitor with good oral activity (IC50=30 nM). Tie2 kinase inhibitor 3 inhibits phosphorylation and signaling of Tie-2 by competing with the ATP binding site of Tie-2 kinase. This inhibition affects the stability and maturity of blood vessels, which has an impact on tumor angiogenesis. Tie2 kinase inhibitor 3 can be used to restrict tumor growth and regulate angiogenesis. | |||||||||||||||||||||
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Keywords
