875638-86-1
875638-86-1
Chemical Structure
HPK1-IN-61
- CAS No.: 875638-86-1
- Formula:C23H22N4O2
- Molecular Weight:386.45
IUPAC Name: 2-amino-5-(3-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N,N-dimethylbenzamide
InChIKey: WXWRMODVCNBNEA-UHFFFAOYSA-N
SMILES: NC1=C(C=C(C2=CN=C3NC=C(C3=C2)C4=C(OC)C=CC=C4)C=C1)C(N(C)C)=O
Biological Activity: HPK1-IN-61 (Compound 1) is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 0.4 nM) and an inhibitor of Abl (IC50 < 0.51 nM). HPK1-IN-61 also shows inhibitory activity against LCK with an IC50 of 24 nM[1].
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HPK1-IN-61 | HPK1-IN-61 (Compound 1) is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 0.4 nM) and an inhibitor of Abl (IC50 < 0.51 nM). HPK1-IN-61 also shows inhibitory activity against LCK with an IC50 of 24 nM. | |||||||||||||||||||||
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References
Keywords
