889768-87-0
889768-87-0
Chemical Structure
GSK-3β-IN-31
- CAS No.: 889768-87-0
- Formula:C18H15NO3
- Molecular Weight:293.32
InChIKey: HUUVVTXUJGLTEU-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C)=C(O)C=C1O)CC2=CC=CC3=CC=CN=C32
Biological Activity: GSK-3β-IN-31 is a glycogen synthase kinase-3β (GSK-3β) inhibitor. GSK-3β-IN-31 binds to the ATP-binding pocket of GSK-3β, forms hydrogen bonds with Lys183 and Ser203, and also engages in π-anion interactions with Asp181 and Asp200 to stabilize the binding conformation. GSK-3β-IN-31 can be used for the research of Alzheimer's disease[1].
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GSK-3β-IN-31 | GSK-3β-IN-31 is a glycogen synthase kinase-3β (GSK-3β) inhibitor. GSK-3β-IN-31 binds to the ATP-binding pocket of GSK-3β, forms hydrogen bonds with Lys183 and Ser203, and also engages in π-anion interactions with Asp181 and Asp200 to stabilize the binding conformation. GSK-3β-IN-31 can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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