910798-82-2
910798-82-2
Chemical Structure
AZ599
- CAS No.: 910798-82-2
- Formula:C25H35N3O4S
- Molecular Weight:473.63
IUPAC Name: (5-(ethylsulfonyl)-2-(tetrahydro-2H-pyran-4-yl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)(4-methylpiperidin-1-yl)methanone
InChIKey: UCMNIYFDRVBMFV-UHFFFAOYSA-N
SMILES: O=C(C=1C=CC2=C(C1)C3=C(N2S(=O)(=O)CC)CCN(C3)C4CCOCC4)N5CCC(C)CC5
Biological Activity: AZ599 is a mixed CB1/CB2 cannabinoid receptor agonist with an EC50 of 49 nM and a Ki of 120 nM for the human CB1 receptor, and a Ki of 9 nM for the human CB2 receptor. AZ599 inhibits hERG potassium channels and CYP enzymes. AZ599 can be used for research on chronic pain[1][2].
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AZ599 | AZ599 is a mixed CB1/CB2 cannabinoid receptor agonist with an EC50 of 49 nM and a Ki of 120 nM for the human CB1 receptor, and a Ki of 9 nM for the human CB2 receptor. AZ599 inhibits hERG potassium channels and CYP enzymes. AZ599 can be used for research on chronic pain. | |||||||||||||||||||||
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References
- [1]. Cheng YX, et al. γ-Carbolines: a novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration. Bioorganic & medicinal chemistry letters. 2012 Feb 15;22(4):1619-24.
- [2]. Wei Z, et al. N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2, 3, 4, 9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration. Bioorganic & medicinal chemistry letters. 2012 Jun 15;22(12):3884-9.
