914453-98-8
Chemical Structure
Ornipressin acetate
Synonym(s): POR-8 acetate
- CAS No.: 914453-98-8
- Formula:C47H67N13O14S2
- Molecular Weight:1042.19 (free base)
InChIKey: LLKMRUBZBURTOK-LQJNFXHPSA-N
SMILES: O=C([C@H](CSSC[C@@H](C(N[C@H](C1=O)CC2=CC=C(O)C=C2)=O)N)NC([C@@H](NC([C@@H](NC([C@](N1)([H])CC3=CC=CC=C3)=O)CCC(N)=O)=O)CC(N)=O)=O)N(CCC4)[C@@H]4C(N[C@@H](CCCN)C(NCC(N)=O)=O)=O.CC(O)=O.[x]
Biological Activity: Ornipressin (POR-8) acetate is a potent vasoconstrictor, hemostatic and renal agent. Ornipressin acetate is a vasopressin agonist specific for the V1 receptor. Ornipressin acetate can be used as a local vasoconstrictor. Ornipressin acetate can reverse the hypotension associated with combine general/epidural anesthesia. Ornipressin acetate has antidiuretic activity. Ornipressin acetate decreases renal vascular resistance and increases renal blood flow in renal failure model[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Ornipressin acetate | 99.63% | Ornipressin (POR-8) acetate is a potent vasoconstrictor, hemostatic and renal agent. Ornipressin acetate is a vasopressin agonist specific for the V1 receptor. Ornipressin acetate can be used as a local vasoconstrictor. Ornipressin acetate can reverse the hypotension associated with combine general/epidural anesthesia. Ornipressin acetate has antidiuretic activity. Ornipressin acetate decreases renal vascular resistance and increases renal blood flow in renal failure model. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. De Kock M, et al. Ornipressin (Por 8): An efficient alternative to counteract hypotension during combined general/epidural anesthesia. Anesth Analg. 2000 Jun;90(6):1301-7. [Content Brief]
- [2]. Fruhstorfer H, et al. Dose-response relation of ornipressin with regard to vasoconstriction in human skin. Br J Anaesth. 1994 Aug;73(2):220-4. [Content Brief]
- [3]. Kam, P. C., & Tay, T. M. (1998). The pharmacology of ornipressin (POR-8): a local vasoconstrictor used in surgery. European journal of anaesthesiology, 15(2), 133–139. [Content Brief]
- [4]. Lenz, K., et al., (1991). Ornipressin in the treatment of functional renal failure in decompensated liver cirrhosis. Effects on renal hemodynamics and atrial natriuretic factor. Gastroenterology, 101(4), 1060–1067. [Content Brief]
Keywords
