93750-14-2
93750-14-2
Chemical Structure
N-1518
- CAS No.: 93750-14-2
- Formula:C22H26N2O5
- Molecular Weight:398.45
IUPAC Name: 4-(2-hydroxy-3-((1-(2-methoxyphenoxy)propan-2-yl)amino)propoxy)isoquinolin-1(2H)-one
InChIKey: BZAQSBHYQKDSGT-UHFFFAOYSA-N
SMILES: O=C1NC=C(C2=C1C=CC=C2)OCC(CNC(COC3=C(OC)C=CC=C3)C)O
Biological Activity: N-1518 is an α and β adrenergic receptor blocker that has competitive antagonism against β1 and α1 receptors, but does not show selectivity for β1 receptors, but shows about 20-fold selectivity for α1 receptors. N-1518 has vasodilatory effects and can be used in the research field of hypertension treatment[1].
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N-1518 | N-1518 is an α and β adrenergic receptor blocker that has competitive antagonism against β1 and α1 receptors, but does not show selectivity for β1 receptors, but shows about 20-fold selectivity for α1 receptors. N-1518 has vasodilatory effects and can be used in the research field of hypertension treatment. | |||||||||||||||||||||
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References
- [1]. T Sugai, et al. [Pharmacological properties of (+/-)-4-[2-hydroxy-3-(3-(2-methoxyphenoxy)-2-propylamino) propoxy]-1 (2H)-isoquinolinone (N-1518), a new combined alpha-and beta-adrenoceptor blocking drug]. Nihon Yakurigaku zasshi. Folia Pharmacologica Japonica 96.3 (1990): 117-127. [Content Brief]
