939681-36-4
939681-36-4
Chemical Structure
G5-7
- CAS No.: 939681-36-4
- Formula:C22H19F2NO3
- Molecular Weight:383.39
IUPAC Name: ethyl 3,5-bis((Z)-2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate
InChIKey: FPAYMMBGZTYNSI-WHYMJUELSA-N
SMILES: O=C(N1C/C(C(/C(C1)=C\C2=CC=CC=C2F)=O)=C/C3=CC=CC=C3F)OCC
Biological Activity: G5-7, an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 induces cell cycle arrest, apoptosis and possesses antiangiogenic effect. G5-7 has the potential for glioma study[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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G5-7 | 98.45% | G5-7, an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 induces cell cycle arrest, apoptosis and possesses antiangiogenic effect. G5-7 has the potential for glioma study. | ||||||||||||||||||||
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