94159-34-9
Chemical Structure
PCSK9-IN-36
- CAS No.: 94159-34-9
- Formula:C21H20O10
- Molecular Weight:432.38
InChIKey: KMOUJOKENFFTPU-RQXATKFSSA-N
SMILES: O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)=CC(O)=C13
Biological Activity: PCSK9-IN-36 is a PCSK9 inhibitor and a flavonoid glycoside derivative. PCSK9-IN-36 binds stably within the surface groove of PCSK9 through hydrophobic interactions involving its flavonoid scaffold and an electrostatic hydrogen-bonding network formed by its polar glycosidic group, thereby competitively blocking the interaction between PCSK9 and the low-density lipoprotein receptor (LDLR). PCSK9-IN-36 can be used for research on hypercholesterolemia[1].
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PCSK9-IN-36 | PCSK9-IN-36 is a PCSK9 inhibitor and a flavonoid glycoside derivative. PCSK9-IN-36 binds stably within the surface groove of PCSK9 through hydrophobic interactions involving its flavonoid scaffold and an electrostatic hydrogen-bonding network formed by its polar glycosidic group, thereby competitively blocking the interaction between PCSK9 and the low-density lipoprotein receptor (LDLR). PCSK9-IN-36 can be used for research on hypercholesterolemia. | |||||||||||||||||||||
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