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Cat. No.: HY-187677

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PCSK9-IN-36

PCSK9-IN-36 is a PCSK9 inhibitor and a flavonoid glycoside derivative. PCSK9-IN-36 binds stably within the surface groove of PCSK9 through hydrophobic interactions involving its flavonoid scaffold and an electrostatic hydrogen-bonding network formed by its polar glycosidic group, thereby competitively blocking the interaction between PCSK9 and the low-density lipoprotein receptor (LDLR). PCSK9-IN-36 can be used for research on hypercholesterolemia.

For research use only. We do not sell to patients.

CAS No.: 94159-34-9
Formula: C₂₁H₂₀O₁₀
Molecular Weight:432.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PCSK9-IN-36 Chemical Structure

CAS No.: 94159-34-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

PCSK9-IN-36 stably binds to the surface groove of PCSK9 with a binding free energy of -22.59 kcal/mol^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 94159-34-9
Molecular Weight 432.38
Formula C₂₁H₂₀O₁₀
SMILES

O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)=CC(O)=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang Y, et al. Integration of molecular docking, molecular dynamics simulations, and free energy calculations identifies a novel flavonoid glycoside as a PCSK9 inhibitor for hypercholesterolemia. Scientific reports. 2026 Jul 16.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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