947018-15-7
947018-15-7
Chemical Structure
J9
- No. CAS: 947018-15-7
- Formula:C12H12N4
- Molecular Weight:212.25
IUPAC Name: 4-cyclopropyl-5-(pyridin-4-yl)pyrimidin-2-amine
InChIKey: PQLYPFZAOUDDHB-UHFFFAOYSA-N
SMILES: NC1=NC=C(C2=CC=NC=C2)C(C3CC3)=N1
Biological Activity: J9 is a small molecule that reverses Dexamethasone (HY-14648) resistance in T-cell acute lymphoblastic leukemia. J9 is lethal to CUTLL1 cells only in the presence of Dexamethasone. J9 inhibits CUTLL1 cell growth with an EC50 of 28 μM in combination with Dexamethasone[1].
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J9 | J9 is a small molecule that reverses Dexamethasone (HY-14648) resistance in T-cell acute lymphoblastic leukemia. J9 is lethal to CUTLL1 cells only in the presence of Dexamethasone. J9 inhibits CUTLL1 cell growth with an EC50 of 28 μM in combination with Dexamethasone. | |||||||||||||||||||||
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