950003-29-9
950003-29-9
Chemical Structure
T5996207
- CAS. Nr.: 950003-29-9
- Formula:C20H28N4O3S2
- Molecular Weight:436.59
IUPAC Name: N-((5-(N,N-diethylsulfamoyl)thiophen-2-yl)methyl)-4-phenylpiperazine-1-carboxamide
InChIKey: MPFYPLDZUAPMEA-UHFFFAOYSA-N
SMILES: O=C(NCC=1SC(=CC1)S(=O)(=O)N(CC)CC)N2CCN(C=3C=CC=CC3)CC2
Biological Activity: T5996207 is a MyD88 inhibitor. T5996207 inhibits LPS-induced MyD88-mediated NF-κB-driven SEAP expression. T5996207 protects mice from lethal staphylococcal enterotoxin B-induced shock. T5996207 can be used for research on acute lung injury and toxic shock[1][2][3][4][5].
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T5996207 | T5996207 is a MyD88 inhibitor. T5996207 inhibits LPS-induced MyD88-mediated NF-κB-driven SEAP expression. T5996207 protects mice from lethal staphylococcal enterotoxin B-induced shock. T5996207 can be used for research on acute lung injury and toxic shock. | |||||||||||||||||||||
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References
- [1]. Zhu L, et al. Design, Synthesis, and Biological Evaluation of a MyD88-Targeted Molecular Glue d21 for the Treatment of Acute Lung Injury. Journal of medicinal chemistry. 2026 Jun 25;69(12):14722-14740. [Content Brief]
- [2]. Olson MA, et al. Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen. Scientific reports. 2015 Sep 18;5:14246. [Content Brief]
- [3]. Chen P. Discovery of 3g as an Orally Bioavailable, TIR Domain Selective, and Potent MyD88 Inhibitor for the Treatment of Acute Lung Injury. Journal of Medicinal Chemistry. 2025 Sep 12;68(18):19626-44. [Content Brief]
- [4]. Chen L. Myeloid differentiation primary response protein 88 (MyD88): the central hub of TLR/IL-1R signaling. Journal of medicinal chemistry. 2020 Sep 15;63(22):13316-29. [Content Brief]
- [5]. Olson M A, et al. Author Correction: Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen[J]. Scientific Reports, 2018, 8(1): 17074.
