959766-47-3
Chemical Structure
CH5015765
- CAS No.: 959766-47-3
- Formula:C16H13ClN4OS
- Molecular Weight:344.82
IUPAC Name: 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(methylthio)-1,3,5-triazin-2-amine
InChIKey: FPTCGMGLTQPTGE-UHFFFAOYSA-N
SMILES: NC1=NC(C2=C(Cl)C=C3C4=C2C=CC=C4COC3)=NC(SC)=N1
Biological Activity: CH5015765 is an orally available Hsp90 inhibitor bound to the N-terminal ATP binding site, with a dissociation constant of 3.4 nM, CH5015765 exerts antiproliferative activity against human cancer cell lines, with IC50 values of 0.46 μM for HCT116 colorectal cancer cells and 0.57 μM for NCI-N87 gastric cancer cells. CH5015765 can be used for the study of cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CH5015765 | 98.01% | CH5015765 is an orally available Hsp90 inhibitor bound to the N-terminal ATP binding site, with a dissociation constant of 3.4 nM, CH5015765 exerts antiproliferative activity against human cancer cell lines, with IC50 values of 0.46 μM for HCT116 colorectal cancer cells and 0.57 μM for NCI-N87 gastric cancer cells. CH5015765 can be used for the study of cancer. | ||||||||||||||||||||
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References
- [1]. Suda A, et al. Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors. Bioorg Med Chem. 2014 Jan 15;22(2):892-905. [Content Brief]
- [2]. Atsushi Suda, et al. Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1136-41. [Content Brief]
