CDK2-IN-59
CDK2-IN-59 is a CDK2 inhibitor with a IC50 of 66.33 μM. CDK2-IN-59 stably interacts within the CDK2 active site and induces apoptosis in breast cancer cells. CDK2-IN-59 can be used for the research of breast cancer.
For research use only. We do not sell to patients.
- Formula: C24H18ClN5O4
- Molecular Weight:475.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK2/CycA2 66.33 μM (IC50) |
CDK2-IN-59 (Compound 7d) (up to 500 μM) potently inhibits the proliferation of MDA-MB-231 breast cancer cells with an IC50 of 5.16 μM[1].
CDK2-IN-59 exhibits reduced cytotoxicity toward L929 murine fibroblast normal cells with an IC50 of 59.10 μM and a selectivity index of 11.45 compared to MDA-MB-231 breast cancer cells[1].
CDK2-IN-59 induces apoptosis in MDA-MB-231 breast cancer cells, driving 14.1% of cells into early apoptosis and 52.7% into late apoptosis[1].
CDK2-IN-59 significantly inhibits CDK2/CyclinA2 enzymatic activity with an IC50 of 66.33 μM[1].
CDK2-IN-59 exhibits strong binding affinity for CDK2 (PDB ID: 4BCQ) with an MM/GBSA binding free energy of -53.28 kcal/mol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 475.88
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Formula C24H18ClN5O4
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SMILES
COC1=CC=C(C2=CC(C3=CC=C(OC4=NC(N)=NC(Cl)=C4)C=C3)=C(C#N)C(N2)=O)C=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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