1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK7-IN-8

CDK7-IN-8 

Cat. No.: HY-143586
Handling Instructions

CDK7-IN-8 is a potent CDK7 inhibitor with IC50 of 54.29 nM. CDK7-IN-8 has inhibitory effect on certain cancer cells and in vivo tumor models.

For research use only. We do not sell to patients.

CDK7-IN-8 Chemical Structure

CDK7-IN-8 Chemical Structure

CAS No. : 2654003-64-0

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CDK7-IN-8 is a potent CDK7 inhibitor with IC50 of 54.29 nM. CDK7-IN-8 has inhibitory effect on certain cancer cells and in vivo tumor models[1].

IC50 & Target[1]

CDK7

54.29 nM (IC50)

In Vitro

CDK7-IN-8 (0-100 nM; 72 hours) has inhibitory effect on HCC70, OVCAR-3, HCT116 and HCC1806 cells, with IC50 of 50.85 nM, 45.31 nM, 25.26 nM and 44.47 nM respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: HCC70, OVCAR-3, HCT116 and HCC1806 cells[1]
Concentration: 0-100 nM
Incubation Time: 72 hours
Result: Exhibited inhibitory effect on HCC70, OVCAR-3, HCT116 and HCC1806 cells, with IC50 of 50.85 nM, 45.31 nM, 25.26 nM and 44.47 nM respectively.
In Vivo

CDK7-IN-8 (20 or 40 mg/kg; i.g., single) has good advantages Pharmacokinetic properties[1].
CDK7-IN-8 (25 mg/kg; p.o., qd, for 21 days) effectively inhibits tumor proliferation with tumor growth inhibition (TGI) value of 81.9%[1].
Pharmacokinetic Parameters of CDK7-IN-8 in male ICR mice[1].

IG (20 mg/kg) IG (40 mg/kg)
T1/2 (h) 1.48 2.99
Tmax (h) 0.50 4.67
Cmax (ng/mL) 3379.92 783.01
AUC0-t (h*ng/mL) 6258.34 7828.87
AUC0-∞ (h*ng/mL) 6375.00 7879.45

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice [1]
Dosage: 20 or 40 mg/kg
Administration: i.g., single (pharmacokinetic analysis)
Result: Showed good advantages Pharmacokinetic properties.
Animal Model: Male BALB/c nude mice (injected with HCT116 tumor cells)[1]
Dosage: 25 mg/kg
Administration: p.o., qd, for 21 days
Result: Effectively inhibited tumor proliferation with tumor growth inhibition (TGI) value of 81.9%.
Molecular Weight

498.62

Formula

C25H38N8O3

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CDK7-IN-8
Cat. No.:
HY-143586
Quantity:
MCE Japan Authorized Agent: