2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK7-IN-8

CDK7-IN-8 is a potent CDK7 inhibitor with IC50 of 54.29 nM. CDK7-IN-8 has inhibitory effect on certain cancer cells and in vivo tumor models.

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CDK7-IN-8 Chemical Structure

CDK7-IN-8 Chemical Structure

CAS No. : 2654003-64-0

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CDK7-IN-8 Related Antibodies

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Description

CDK7-IN-8 is a potent CDK7 inhibitor with IC50 of 54.29 nM. CDK7-IN-8 has inhibitory effect on certain cancer cells and in vivo tumor models[1].

IC50 & Target[1]

CDK7

54.29 nM (IC50)

In Vitro

CDK7-IN-8 (0-100 nM; 72 hours) has inhibitory effect on HCC70, OVCAR-3, HCT116 and HCC1806 cells, with IC50 of 50.85 nM, 45.31 nM, 25.26 nM and 44.47 nM respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CDK7-IN-8 Related Antibodies

Cell Proliferation Assay

Cell Line: HCC70, OVCAR-3, HCT116 and HCC1806 cells[1]
Concentration: 0-100 nM
Incubation Time: 72 hours
Result: Exhibited inhibitory effect on HCC70, OVCAR-3, HCT116 and HCC1806 cells, with IC50 of 50.85 nM, 45.31 nM, 25.26 nM and 44.47 nM respectively.
In Vivo

CDK7-IN-8 (20 or 40 mg/kg; i.g., single) has good advantages Pharmacokinetic properties[1].
CDK7-IN-8 (25 mg/kg; p.o., qd, for 21 days) effectively inhibits tumor proliferation with tumor growth inhibition (TGI) value of 81.9%[1].
Pharmacokinetic Parameters of CDK7-IN-8 in male ICR mice[1].

IG (20 mg/kg) IG (40 mg/kg)
T1/2 (h) 1.48 2.99
Tmax (h) 0.50 4.67
Cmax (ng/mL) 3379.92 783.01
AUC0-t (h*ng/mL) 6258.34 7828.87
AUC0-∞ (h*ng/mL) 6375.00 7879.45

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice [1]
Dosage: 20 or 40 mg/kg
Administration: i.g., single (pharmacokinetic analysis)
Result: Showed good advantages Pharmacokinetic properties.
Animal Model: Male BALB/c nude mice (injected with HCT116 tumor cells)[1]
Dosage: 25 mg/kg
Administration: p.o., qd, for 21 days
Result: Effectively inhibited tumor proliferation with tumor growth inhibition (TGI) value of 81.9%.
Molecular Weight

498.62

Formula

C25H38N8O3
CAS No.
SMILES

CC(C1=C2N(N=C1)C(NC3CCN(CC3)C(O[C@@H]4CN(CC4)C(/C=C/CN(C)C)=O)=O)=NC(C)=N2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDK7-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK7-IN-82654003-64-0CDKCyclin dependent kinaseCDK7HCT116 cellsICR miceCancerInhibitorinhibitorinhibit

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