Chem-0199
Chem-0199 is an Adipocyte Enhancer-Binding Protein 1 (AEBP1) inhibitor. Chem-0199 can disrupt the interaction between AEBP1 and CKAP4, thereby enhances antitumor immunity. Chem-0199 can inhibit Akt phosphorylation (p-Akt) and downregulates PD-L1 expression. Chem-0199 can be used for the research of cancer, such as colon cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C13H18N2O2
- Molecular Weight:234.29
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Chem-0199 inhibits the binding of AEBP1 to CKAP4 in human/mouse cancer-associated fibroblasts (hCAFs/mCAFs)[1].
Chem-0199 (10-100 μM) inhibits Akt phosphorylation (p-Akt) and downregulates PD-L1 expression in mCAFs[1].
Chem-0199 (10-100 μM, 48 h) significantly increases the proportion of IFN-γ+ and TNF-α+CD8+ T cells and restores T cell cytotoxicity in mouse splenic T cells[1].
Chem-0199 (1-20 μM, 72 h) shows no significant inhibitory effect on the proliferation of multiple tumor cells (MC38, CT26, B16-F10)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:WT C57BL/6 mice with MC38 tumor [1]
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Dosage:3, 10 and 30 mg/kg
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Administration:Intraperitoneally injection
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Result:Reduced tumor volume.
Further enhanced tumor inhibition and prolonged mouse survival combined with anti-CTLA-4 antibody.
Increased the proportion of IFN-γ+ and TNF-α+CD8+ T cells.
Showed no abnormalities in blood routine (WBC, RBC, Hb, PLT) or H&E staining of heart, liver, lung, kidney, and intestine tissues.
Chemical Information
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Molecular Weight 234.29
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Formel C13H18N2O2
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SMILES
CC1(C)N(O)[C@H](C2=CC=CC=C2)[N+]([O-])=C1CC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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