HOXD11 - homeobox D11 Gene

Also Known as HOX4; HOX4F

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3237

About HOXD11

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:176,107,280-176,115,679 (from NCBI)

This gene has 2 transcripts (splice variants), 185 orthologues, 42 paralogues and is associated with 32 phenotypes. Biased expression in endometrium (RPKM 10.2), colon (RPKM 4.5) and 2 other tissues.

Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]

HOXD11 Products (1)

mRNA	Protein	Name
NM_021192.3	NP_067015.2	homeobox protein Hox-D11

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXD11 Protein Structure

DUF3528

Homeobox

0
100
200
300
338 a.a.

Protein Preferred Names	Protein Names
homeobox protein Hox-D11	Hox-4.6, mouse, homolog of

Related Diseases

Diseases	Alias
Synpolydactyly	Syndactyly Type 2 Syndactyly, Type 2 Spd
Syndactyly, Type V	Syndactyly Type 5 SDTY5 Syndactyly With Metacarpal And Metatarsal Fusion Syndactyly With Associated Metacarpal And Metatarsal Fusion Postaxial Syndactyly With Metacarpal Synostosis Sd5 Syndactyly 5 Syndactyly Type V
Brachydactyly-Syndactyly Syndrome	BDSD Brachydactyly-Syndactyly-Oligodactyly Syndrome Brachydactyly-Syndactyly, Zhao Type BDSDO
Small-Cell Carcinoma Of The Ovary Of Hypercalcemic Type	Hypercalcemic Type Ovarian Small Cell Carcinoma Small Cell Carcinoma Of The Ovary, Hypercalcemic Type Ovarian Small Cell Carcinoma, Hypercalcemic Type
Laurin-Sandrow Syndrome	Sandrow Syndrome Tetramelic Mirror-Image Polydactyly Mirror-Image Polydactyly Mirror Hands And Feet With Nasal Defects Tmip LSS Mip Mirror Hands And Feets-Nasal Defects Syndrome Fibula And Ulna, Duplication Of, With Absence Of Tibia And Radius Miccor Hands And Feet With Nasal Defects Mipduplication Of Fibuland Ulna With Absence Of Tibia And Radius Fibula Ulna Duplication Tibia Radius Absence Laurin Sandrow Syndrome Duplication Of Fibula And Ulna With Absence Of Tibia And Radius Segmental Laurin-Sandrow Syndrome Laurin-Sandrow Syndrome, Segmental
Clubfoot	Congenital Talipes Equinovarus Congenital Clubfoot Congenital Equinovarus Equinovarus Deformity Of Foot Club Foot
Brachydactyly
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS06324	HOXD11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HOXD11	MGD	MGI:96203
Macaca mulatta	HOXD11	VGNC	VGNC:104537
Felis catus	HOXD11	VGNC	VGNC:67632
Rattus norvegicus	HOXD11	RGD	RGD:7730597
Canis familiaris	HOXD11	VGNC	VGNC:41763
Bos taurus	HOXD11	VGNC	VGNC:29931
Others	HOXD11	NCBI