CRNN - cornulin Gene

Also Known as DRC1; PDRC1; SEP53; C1orf10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 49860

About CRNN

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,409,243-152,414,263 (from NCBI)

This gene has 1 transcript (splice variant), 327 orthologues and 21 paralogues. Restricted expression toward esophagus (RPKM 2138.4).

Summary

This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]

CRNN Products (1)

mRNA Protein Name
NM_016190.3 NP_057274.1 cornulin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cell-cell adhesion IDA
IDA: Inferred from direct assay
2631556 GOA
involved in cellular response to cytokine stimulus IDA
IDA: Inferred from direct assay
30009832 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
30009832 GOA
involved in positive regulation of cell cycle G1/S phase transition IMP
IMP: Inferred from mutant phenotype
30009832 GOA
involved in positive regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
30009832 GOA
involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
30009832 GOA
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
30009832 GOA
involved in response to heat IDA
IDA: Inferred from direct assay
11606197 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15854041 GOA
located in membrane IDA
IDA: Inferred from direct assay
2980212 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRNN Protein Structure

S_100

S_100: S-100/ICaBP type calcium binding domain (4 - 45)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 495 a.a.
Protein Preferred Names Protein Names

cornulin

  • 53 kDa putative calcium-binding protein

Recombinant CRNN Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70116 Cornulin Protein, Human (His) Q9UBG3 (M1-S140) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
Squamous Cell Carcinoma

  • Epidermoid Carcinoma

  • Squamous Cell Cancer

  • Carcinoma, Squamous Cell

  • Squamous Cell Skin Cancer

  • Malignant Squamous Cell Tumor

  • Squamous Carcinoma

  • Squamous Cell Epithelioma

  • Carcinoma Squamous Cell

  • Neoplasms, Squamous Cell

  • Squamous Cell Carcinoma - Category

  • Malignant Squamous Cell Neoplasm

  • Squamous Cell Carcinoma Of Skin
Oral Squamous Cell Carcinoma

  • Mouth Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Mouth
Psoriasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03192 CRNN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21317 Crnn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27836 Crnn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CRNN VGNC VGNC:71397
Mus musculus CRNN MGD MGI:2685861
Canis familiaris CRNN VGNC VGNC:39626
Rattus norvegicus CRNN RGD RGD:1311778
Bos taurus CRNN VGNC VGNC:27722
Others CRNN NCBI