ADAM15 - ADAM metallopeptidase domain 15 Gene

Also Known as MDC15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8751

About ADAM15

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:155,051,316-155,062,775 (from NCBI)

This gene has 32 transcripts (splice variants), 192 orthologues and 20 paralogues. Ubiquitous expression in skin (RPKM 41.3), esophagus (RPKM 32.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the Integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

ADAM15 Products (9)

mRNA	Protein	Name
NM_001261464.2	NP_001248393.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 7 preproprotein
NM_001261465.2	NP_001248394.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 8 preproprotein
NM_001261466.2	NP_001248395.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 9 preproprotein
NM_003815.5	NP_003806.3	disintegrin and metalloproteinase domain-containing protein 15 isoform 2 preproprotein
NM_207191.3	NP_997074.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 1 preproprotein
NM_207194.3	NP_997077.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 3 preproprotein
NM_207195.3	NP_997078.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 4 preproprotein
NM_207196.3	NP_997079.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 5 preproprotein
NM_207197.3	NP_997080.1	disintegrin and metalloproteinase domain-containing protein 15 isoform 6 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	10531379	GOA
enables immunoglobulin receptor binding	IPI IPI: Inferred from physical interaction	12777399	GOA
enables integrin binding	IMP IMP: Inferred from mutant phenotype	22505472	GOA
enables metallopeptidase activity	IDA IDA: Inferred from direct assay	12777399	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10531379	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
NOT involved in apoptotic process	IDA IDA: Inferred from direct assay	22505472	GOA
involved in cellular response to phorbol 13-acetate 12-myristate	IDA IDA: Inferred from direct assay	22505472	GOA
involved in immune response to tumor cell	IDA IDA: Inferred from direct assay	22505472	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	22505472	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	22505472	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	22505472	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	22505472	GOA
involved in negative regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	22505472	GOA
involved in negative regulation of receptor binding	IMP IMP: Inferred from mutant phenotype	22505472	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cell surface	IDA IDA: Inferred from direct assay	22505472	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	22505472	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM15 Protein Structure

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
800
863 a.a.

Protein Preferred Names	Protein Names
disintegrin and metalloproteinase domain-containing protein 15	MDC-15

ADAM15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ADAM15	Q13444	SP4	Homo sapiens	Q02446	Y2H Array	25416956
Intra	ADAM15	Q13444	OSTF1	Homo sapiens	Q92882	Peptide Array	25825872
Intra	ADAM15	Q13444	OSTF1	Homo sapiens	Q92882	Phage Display	25825872
Intra	ADAM15	Q13444	LCK	Homo sapiens	P06239	Peptide Array	25825872
Intra	ADAM15	Q13444	LCK	Homo sapiens	P06239	Pull Down	11741929
Intra	ADAM15	Q13444	LCK	Homo sapiens	P06239	Anti Bait CoIP	11741929
Intra	ADAM15	Q13444	SNX33	Homo sapiens	Q8WV41	Peptide Array	25825872
Intra	ADAM15	Q13444	SNX33	Homo sapiens	Q8WV41	Phage Display	25825872
Intra	ADAM15	Q13444	SNX33	Homo sapiens	Q8WV41	Filter Binding	16374509
Intra	ADAM15	Q13444	SH3PXD2A	Homo sapiens	Q5TCZ1	Peptide Array	25825872
Intra	ADAM15	Q13444	SH3PXD2A	Homo sapiens	Q5TCZ1	Phage Display	25825872
Intra	ADAM15	Q13444	HCK	Homo sapiens	P08631	Filter Binding	16374509
Intra	ADAM15	Q13444	HCK	Homo sapiens	P08631	Pull Down	11741929
Intra	ADAM15	Q13444	HCK	Homo sapiens	P08631	Phage Display	25825872
Intra	ADAM15	Q13444	NUP62	Homo sapiens	P37198	Y2H Array	25416956
Intra	ADAM15	Q13444	GRB2	Homo sapiens	P62993	Filter Binding	16374509
Intra	ADAM15	Q13444	GRB2	Homo sapiens	P62993	Peptide Array	25825872
Intra	ADAM15	Q13444	FYN	Homo sapiens	P06241	Pull Down	11741929
Intra	ADAM15	Q13444	SRC	Homo sapiens	P12931	Phage Display	25825872
Intra	ADAM15	Q13444	SRC	Homo sapiens	P12931	Pull Down	11741929
Intra	ADAM15	Q13444	BTK	Homo sapiens	Q06187	Phage Display	25825872
Intra	ADAM15	Q13444	BTK	Homo sapiens	Q06187	Peptide Array	25825872
Intra	ADAM15	Q13444	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
Intra	ADAM15	Q13444	RBPMS	Homo sapiens	Q93062	Y2H Prey Pooling	25416956
Intra	ADAM15	Q13444	FHL3	Homo sapiens	Q13643	Y2H Array	25416956
Intra	ADAM15	Q13444	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	25416956
Intra	ADAM15	Q13444	BANP	Homo sapiens	Q8N9N5	Validated Y2H	25416956
Intra	ADAM15	Q13444	SNX9	Homo sapiens	Q9Y5X1	Y2H	10531379
Intra	ADAM15	Q13444	SNX9	Homo sapiens	Q9Y5X1	Peptide Array	25825872
Intra	ADAM15	Q13444	SNX9	Homo sapiens	Q9Y5X1	Phage Display	25825872
Intra	ADAM15	Q13444	PACSIN3	Homo sapiens	Q9UKS6	Filter Binding	16374509
Intra	ADAM15	Q13444	PACSIN3	Homo sapiens	Q9UKS6	Y2H	10531379
Intra	ADAM15	Q13444	LYN	Homo sapiens	P07948	Phage Display	25825872
Intra	ADAM15	Q13444	LYN	Homo sapiens	P07948	Filter Binding	16374509
Intra	ADAM15	Q13444	NPHP1	Homo sapiens	O15259	Phage Display	25825872
Intra	ADAM15	Q13444	NPHP1	Homo sapiens	O15259	Peptide Array	25825872

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ADAM15 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P75533	ADAM15 Protein, Human (HEK293, His, solution)	Q13444 (D207-T696)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75534	ADAM15 Protein, Human (CHO, His)	Q13444 (D207-T696)	≥ 95%, as determined by reducing SDS-PAGE.

ADAM15 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82905	ADAM15 Antibody (YA2650)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Sorsby Fundus Dystrophy	SFD Fundus Dystrophy, Pseudoinflammatory, Of Sorsby Sorsby'S Fundus Dystrophy Macular Dystrophy, Hemorrhagic Hemorrhagic Macular Dystrophy Pseudoinflammatory Fundus Dystrophy Of Sorsby Sorsby'S Pseudoinflammatory Macular Dystrophy Sorsby Pseudoinflammatory Fundus Dystrophy Dystrophy, Fundus, Sorsby
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-N0863	Methyl protodioscin		99.67%	Unkown
HY-RS00270	ADAM15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18692	Adam15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25179	Adam15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ADAM15	VGNC	VGNC:37575
Macaca mulatta	ADAM15	VGNC	VGNC:69477
Felis catus	ADAM15	VGNC	VGNC:59576
Bos taurus	ADAM15	VGNC	VGNC:25606
Rattus norvegicus	ADAM15	RGD	RGD:620402
Mus musculus	ADAM15	MGD	MGI:1333882
Others	ADAM15	NCBI