MMV665917
MMV665917 is an orally active piperazine derivative with anti-Cryptosporidium parvum activity with an EC90 of 15 μM. MMV665917 significantly reduces the parasite load in a porcine model infected with C. hominis, decreases ovarian excretion, alleviates diarrhea symptoms and reduces intestinal mucosal damage. MMV665917 can be used for research on Cryptosporidium parvum disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 904576-65-4
- Formel: C16H16ClN7O
- Molecular Weight:357.80
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-8 | CC50 |
>100 μM
Compound: 1; MMV665917
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Cytotoxicity against human HCT8 cells assessed as reduction in cell viability after 48 hrs by CellTiter aqueous assay
Cytotoxicity against human HCT8 cells assessed as reduction in cell viability after 48 hrs by CellTiter aqueous assay
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[PMID: 34342443] |
| Huh-7 | CC50 |
>100 μM
Compound: GNF-Pf-3446
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NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
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[PMID: 18579783] |
Chemical Information
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CAS. Nr. 904576-65-4
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Molecular Weight 357.80
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Formel C16H16ClN7O
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SMILES
O=C(NC1=CC=C(C([H])=C1)Cl)N2CCN(CC2)C3=NN4C(C=C3)=NN=C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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