Bioactive limonoid and triterpenoid constituents of Turraea pubescens

  • J Nat Prod. 2013 Jun 28;76(6):1166-74. doi: 10.1021/np400276q.
Chun-Mao Yuan  1 ,  Gui-Hua Tang ,  Yu Zhang ,  Xiao-Ying Wang ,  Ming-Ming Cao ,  Feng Guo ,  Yan Li ,  Ying-Tong Di ,  Shun-Lin Li ,  Hui-Ming Hua ,  Hong-Ping He ,  Xiao-Jiang Hao
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
PMID: 23734701 DOI: 10.1021/np400276q
Abstract

Eleven new limonoids, turrapubins A-K (1-11), and three new triterpenoids (12-14), along with 14 known compounds, were isolated from the twigs of Turraea pubescens. The structures of 1-14 were elucidated on the basis of NMR and MS analysis. Compounds 12, 16, 18, and 19 exhibited inhibitory activities against lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. In addition, compounds 2, 11, 18, and 26 exhibited inhibitory activities against brine shrimp larvae (Artemia salina) at 100 ppm with the corrected mortality ranging from 81.7% to 100%.