Tricholopardins A and B, Anti-inflammatory Terpenoids from the Fruiting Bodies of Tricholoma pardinum

  • J Nat Prod. 2019 Jan 25;82(1):45-50. doi: 10.1021/acs.jnatprod.8b00460.
Tao Feng  1 ,  Xiao-Qing Gan  1 ,  Yun-Li Zhao  2 ,  Shuai-Bing Zhang  1 ,  He-Ping Chen  1 ,  Juan He  1 ,  Yong-Sheng Zheng  1 ,  Huan Sun  1 ,  Rong Huang  1 ,  Zheng-Hui Li  1 ,  Ji-Kai Liu  1
Affiliations
  • 1. School of Pharmaceutical Sciences , South-Central University for Nationalities , Wuhan 430074 , People's Republic of China.
  • 2. State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany , Kunming 650201 , People's Republic of China.
PMID: 30629435 DOI: 10.1021/acs.jnatprod.8b00460
Abstract

Two new Tricholoma Terpenoids, tricholopardins A and B, were isolated from the fruiting bodies of the basidiomycetes Tricholoma pardinum. Their structures were elucidated by spectroscopic methods, as well as electronic circular dichroism and optical rotatory dispersion calculations. Tricholopardin A potently inhibited nitric oxide production in lipopolysaccharide-induced RAW264.7 macrophages with an IC50 of 0.08 μM. Its anti-inflammatory effects on three inflammatory mediators were also evaluated. A plausible biosynthetic pathway for these products is discussed.