VRX0466617
Based on 1 Customer Validation
VRX0466617 is a selective and ATP-competitive Chk2 inhibitor with an IC50 of 120 nM and a Ki of 11 nM. VRX0466617 does not inhibit the related Chk1 activity. VRX0466617 can be used in the study of cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.91%
- CAS. Nr.: 926906-64-1
- Formel: C19H20BrN5O2S
- Molecular Weight:462.36
-
Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
Cell Cycle/DNA Damage Compound Library
HY-L004
-
Kinase Inhibitor Library
HY-L009
-
Anti-Cancer Compound Library
HY-L025
-
Anti-Aging Compound Library
HY-L034
-
Cancer Stem Cells Compound Library
HY-L135
-
Highly Selective Inhibitors Library
HY-L158
-
Serine/Threonine Kinase Inhibitor Library
HY-L164
-
Multi-Target Compound Library
HY-L176
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Posttranslational Modification Library
HY-L226
Biologische Aktivität
|
Chk1 120 nM (IC50) |
Chk1 11 nM (Ki) |
VRX0466617 (10-30 μM) inhibits both the autophosphorylation of Chk2 and the phosphorylation of Cdc25C substrate in vitro kinase reactions[1].
VRX0466617 (0.05-10 μM; 30-180 min) inhibits the phosphorylation of Chk2 Ser19 and Ser33-35, but not of Chk2 Thr68 in ionizing radiation (IR)-induced cells[1].
VRX0466617 induces the phosphorylation of Chk2 Thr68 in the absence of DNA damage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:LCL-N cells treated with ionizing radiation (IR).
-
Concentration:0.05 μM, 0.5 μM, 5 μM, 10 μM
-
Incubation Time:30 min, 180 min
-
Result:Markedly inhibited the phosphorylation of Ser33-35 and, to a less extent, of Ser19, but not of Thr68.
Chemical Information
-
CAS. Nr. 926906-64-1
-
Appearance Solid
-
Molecular Weight 462.36
-
Formel C19H20BrN5O2S
-
Color White to off-white
-
SMILES
OCC(C)NC(C(C(NS1)=O)=C1NC2=CC=C(NC3=CC=C(Br)C=C3)C=C2)=N
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Reinheit & Dokumentation
-
Data Sheet (268 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Powered by Bioz