(Z)-Isbogrel
(Z)-Isbogrel ((Z)-CV-4151) is a potent thromboxane A2 (TxA2) synthase inhibitor with an IC50 of 0.9 nM. (Z)-Isbogrel inhibits serum TxB2 production, with an ED50 of 0.01 mg/kg upon intravenous administration and an ED50 of 0.05 mg/kg upon oral administration in rats, and it exhibits no PAF receptor antagonistic activity. (Z)-Isbogrel can be used in research related to cardiovascular and cerebrovascular diseases.
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- CAS. Nr.: 89667-39-0
- Formel: C18H19NO2
- Molecular Weight:281.36
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
TXA2 0.9 nM (IC50) |
In Vitro
(Z)-Isbogrel potently inhibits thromboxane A2 synthase activity in human platelet microsomes. When TxB2 production is measured using PGH2 as the substrate, the IC50 value is 0.9 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 89667-39-0
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Molecular Weight 281.36
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Formel C18H19NO2
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SMILES
C(=C/CCCCC(O)=O)(\C1=CC=CC=C1)/C=2C=CC=NC2
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Synonyms
(Z)-CV-4151
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(Z)-Isbogrel Related Classifications
HY-119890A Related Classifications
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