3045469-78-8
Chemical Structure
AZD4956
- CAS No.: 3045469-78-8
- Formula:C28H25Cl2N5O4
- Molecular Weight:566.44
InChIKey: YDKFDCIDSWMRSF-MRXNPFEDSA-N
SMILES: ClC1=CC=C(C#N)C(CN2C3=NC=NC(OC4(C)CC4)=C3N=C2C5=CC=CC(OCC[C@@H](C)C(O)=O)=C5Cl)=C1
Biological Activity: AZD4956 is a potent and selective DNA polymerase theta (POLQ) inhibitor. AZD4956 exhibits an IC50 value of less than 3 μmol/L against POLQ and 3.4 μmol/L against MMEJ. AZD4956 suppresses the MMEJ pathway and enhances the activity of DNA-damaging agents in HRR-deficient cellular contexts. AZD4956 shows antitumor activity in BRCA1/2-mutated triple-negative breast cancer and prostate cancer models. AZD4956 can be used for the study of homologous recombination-deficient tumors[1].
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AZD4956 | AZD4956 is a potent and selective DNA polymerase theta (POLQ) inhibitor. AZD4956 exhibits an IC50 value of less than 3 μmol/L against POLQ and 3.4 μmol/L against MMEJ. AZD4956 suppresses the MMEJ pathway and enhances the activity of DNA-damaging agents in HRR-deficient cellular contexts. AZD4956 shows antitumor activity in BRCA1/2-mutated triple-negative breast cancer and prostate cancer models. AZD4956 can be used for the study of homologous recombination-deficient tumors. | |||||||||||||||||||||
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