CENPI - centromere protein I Gene

Also Known as LRPR1; CENP-I; FSHPRH1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2491

About CENPI

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:101,098,204-101,181,859 (from NCBI)

This gene has 8 transcripts (splice variants) and 208 orthologues. Broad expression in lymph node (RPKM 1.1), appendix (RPKM 0.7) and 22 other tissues.

Summary

This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal. The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. Mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jan 2016]

CENPI Products (4)

mRNA	Protein	Name
NM_001318521.2	NP_001305450.1	centromere protein I isoform 2
NM_001318523.1	NP_001305452.1	centromere protein I isoform 3
NM_001386188.2	NP_001373117.1	centromere protein I isoform 1
NM_006733.3	NP_006724.2	centromere protein I isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20212317	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of inner kinetochore	IPI IPI: Inferred from physical interaction	36085283	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	20212317	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPI Protein Structure

CENP-I

0
200
400
600
756 a.a.

Protein Preferred Names	Protein Names
centromere protein I	FSH primary response 1

CENPI Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CENPI	Q92674	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	CENPI	Q92674	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Filippi Syndrome	Scott Craniodigital Syndrome With Mental Retardation Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome FLPIS Scott Bryant Graham Syndrome Craniodigital-Intellectual Disability Syndrome Scott Craniodigital Syndrome Scott-Bryant-Graham Syndrome Syndactyly, Type I, With Microcephaly And Mental Retardation Syndactyly Type I With Microcephaly And Intellectual Disability Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly Craniodigital Syndrome With Intellectual Disability Craniodigital Syndrome-Intellectual Disability Syndrome Craniodigital Syndrome-Intellectual Disability, Scott Type Intellectual Disability-Craniodigital Syndrome
Chromosome 17p13.3, Centromeric, Duplication Syndrome	Chromosome 17p13.3 Duplication Syndrome 17p13.3 Duplication Syndrome 17p13.3 Microduplication Syndrome Trisomy 17p13.3 Chromosome 17p13.3 Centromeric Duplication Syndrome Dup(17)(P13.3)

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02481	CENPI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CENPI	RGD	RGD:2631
Macaca mulatta	CENPI	VGNC	VGNC:97749
Bos taurus	CENPI	VGNC	VGNC:27178
Canis familiaris	CENPI	VGNC	VGNC:39105
Mus musculus	CENPI	MGD	MGI:2147897
Felis catus	CENPI	VGNC	VGNC:103728
Others	CENPI	NCBI