Antimalarial agent 18
Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibits P. falciparum (IC50=50 nM) and A. baumanii (IC50=390 nM).
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- CAS No.: 3037689-82-7
- Formule: C23H44NO9P
- Masse moléculaire:509.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
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Plasmodium |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MRC5 | CC50 |
40.3 μM
Compound: 13j
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability
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[PMID: 36399924] |
Antimalarial agent 18 (compound 13j) is the long chain octanoyl analog, shows cytotoxicity against MRC-5 fibroblasts with an IC50 value of 40.3 μM[1].
Antimalarial agent 18 poorly inhibits avirulent M. tuberculosis strain (H37Ra) with an IC50 value >64 μM[1].
Antimalarial agent 18 may serve as a lead for future analog development of MEP pathway inhibitors against Gram-negative pathogens in general, and A. baumannii in particular[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3037689-82-7
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Masse moléculaire 509.57
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Formule C23H44NO9P
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SMILES
CCCCCCCC(OCOP(CCCC(N(O)C)=O)(OCOC(CCCCCCC)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimalarial agent 18 Related Classifications
HY-151965 Related Classifications
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