Asp-02
Asp-02 is an orally active AMPK activator. Asp-02 reduces non-fasting blood glucose levels, improves body weight, and normalizes elevated serum levels of aspartate transaminase (SGOT), alanine transaminase (SGPT), alkaline phosphatase (ALP), urea and creatinine. Asp-02 can be used in the research of type 2 diabetes.
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- CAS No.: 86711-45-7
- Formule: C23H20O2
- Masse moléculaire:328.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Asp-02 exhibits favourable drug-like ADME properties, including high intestinal permeability (3724.85 nm/s), 100% predicted oral absorption, and limited CNS penetration, indicating good pharmacokinetic potential[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Albino Wistar (8-12 weeks old, 140-180 g, male and female, alloxan-nicotinamide-induced type 2 diabetes)[1]
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Dosage:10 mg/kg
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Administration:p.o.; daily; 25 days
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Result:Reduced non-fasting blood glucose from 559.0 mg/dL on Day 0 to 99.3 mg/dL on Day 25, corresponding to an 82.23% reduction in female rats.
Increased body weight by 15.20% over the 25-day period in female rats.
Reduced non-fasting blood glucose from 517.5 mg/dL on Day 0 to 75.5 mg/dL on Day 25, corresponding to an 85.41% reduction in male rats.
Increased body weight by 36.61% over the 25-day period in male rats.
Normalized serum biochemical parameters to near-control values: reduced SGOT to 205 IU/L, SGPT to 81 IU/L, ALP to 214 IU/L, urea to ~57 mg/dL, and creatinine to ~0.93 mg/dL in female rats; reduced urea to ~51 mg/dL and creatinine to ~0.95 mg/dL, with comparable improvements in hepatic enzyme levels in male rats.
Chemical Information
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CAS No. 86711-45-7
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Masse moléculaire 328.41
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Formule C23H20O2
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SMILES
O=C(C1=CC=C(C)C=C1)C=CC2=CC=C(C=C2)OCC3=CC=CC=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Asp-02 Related Classifications
HY-W083125 Related Classifications
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- Asp-02
- 86711-45-7
- Asp02
- Asp 02
- AMPK
- Aminotransferases (Transaminases)
- Phosphatase
- type 2 diabetes
- human AMPK α2β2 heterotrimers
- alloxan-nicotinamide-induced type 2 diabetic model
- ADME properties
- AMP-activated protein kinase
- Wistar rats
- AMPK α2β2γ1
- AMPK allosteric drug and metabolite site
- Claisen-Schmidt condensation
- human AMPK α2β1 heterotrimers
- Inhibitor
- inhibitor
- inhibit