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MAPK11 - mitogen-activated protein kinase 11 Gene

Also Known as P38B; SAPK2; p38-2; PRKM11; SAPK2B; p38Beta; P38BETA2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5600

About MAPK11

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,263,713-50,270,380 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 19 paralogues. Ubiquitous expression in fat (RPKM 13.9), brain (RPKM 10.1) and 22 other tissues.

Summary

This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

MAPK11 Products (3)

mRNA	Protein	Name
XM_047441447.1	XP_047297403.1	mitogen-activated protein kinase 11 isoform X1
NR_110887.2
NM_002751.7	NP_002742.3	mitogen-activated protein kinase 11

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables MAP kinase activity	IDA IDA: Inferred from direct assay	8663524	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17254968	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	35857590	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in cellular response to UV-B	IDA IDA: Inferred from direct assay	35857590	GOA
involved in cellular response to interleukin-1	IDA IDA: Inferred from direct assay	8663524	GOA
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in p38MAPK cascade	IDA IDA: Inferred from direct assay	10330143	GOA
NOT involved in positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	23483889	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	8663524	GOA
involved in stress-activated protein kinase signaling cascade	IDA IDA: Inferred from direct assay	35857590	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK11 Protein Structure

Pkinase

0
100
200
300
364 a.a.

Protein Preferred Names	Protein Names
mitogen-activated protein kinase 11	MAP kinase 11 MAP kinase p38 beta mitogen-activated protein kinase p38 beta mitogen-activated protein kinase p38-2 stress-activated protein kinase-2 stress-activated protein kinase-2b

MAPK11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	MAPK11	Q15759	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	MAPK11	Q15759	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	MAPK11	Q15759	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	MAPK11	Q15759	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	MAPK11	Q15759	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	MAPK11	Q15759	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	MAPK11	Q15759	MAPKAPK3	Homo sapiens	Q16644	Y2H	21988832
Intra	MAPK11	Q15759	MAPKAPK3	Homo sapiens	Q16644	TAP	23602568
Intra	MAPK11	Q15759	GIPC1	Homo sapiens	O14908-2	Y2H Pooling	32814053
Intra	MAPK11	Q15759	GIPC1	Homo sapiens	O14908-2	Y2H Array	32814053
Intra	MAPK11	Q15759	GIPC1	Homo sapiens	O14908-2	Validated Y2H	32814053
Intra	MAPK11	Q15759	ZNHIT1	Homo sapiens	O43257	Pull Down	17380123
Intra	MAPK11	Q15759	ZNHIT1	Homo sapiens	O43257	Protein Kinase Assay	17380123
Intra	MAPK11	Q15759	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	MAPK11	Q15759	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	MAPK11	Q15759	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	MAPK11	Q15759	TP53	Homo sapiens	P04637	Protein Kinase Assay	17254968
Intra	MAPK11	Q15759	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	MAPK11	Q15759	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	MAPK11	Q15759	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	MAPK11	Q15759	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	MAPK11	Q15759	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	MAPK11	Q15759	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

MAPK11 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P85311	p38β Antibody (YA5003)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Disorder Of Sexual Development	Disorder Of Sex Development Sex Development Disorder Sex Differentiation Disease Dsd Disorders Of Sex Development Sex Differentiation Disorders
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Spinocerebellar Ataxia, X-Linked 5	SCAX5 X-Linked Spinocerebellar Ataxia 5 X-Linked Non Progressive Cerebellar Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-186241	NuP-3	Inhibitor	/	Unkown
HY-RS08098	MAPK11 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08099	Mapk11 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08100	Mapk11 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAPK11	MGD	MGI:1338024
Felis catus	MAPK11	VGNC	VGNC:68165
Macaca mulatta	MAPK11	VGNC	VGNC:74642
Rattus norvegicus	MAPK11	RGD	RGD:1309340
Bos taurus	MAPK11	VGNC	VGNC:31214
Others	MAPK11	NCBI