SYMPK - symplekin scaffold protein Gene

Also Known as SPK; SYM; Pta1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8189

About SYMPK

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,815,410-45,863,147 (from NCBI)

This gene has 18 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in testis (RPKM 32.3), spleen (RPKM 15.5) and 25 other tissues.

Summary

This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]

SYMPK Products (1)

mRNA Protein Name
NM_004819.3 NP_004810.2 symplekin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
14707147 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of protein binding IMP
IMP: Inferred from mutant phenotype
29158257 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
8769423 GOA
located in nuclear stress granule IDA
IDA: Inferred from direct assay
14707147 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
8769423 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYMPK Protein Structure

DUF3453

DUF3453: Domain of unknown function (DUF3453) (117 - 351)

Symplekin_C

Symplekin_C: Symplekin tight junction protein C terminal (887 - 1069)

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  • 200
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  • 1200
  • 1274 a.a.
Protein Preferred Names Protein Names

symplekin

SYMPK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SYMPK Q92797 CPSF2 Homo sapiens Q9P2I0
Anti Bait CoIP
18288197
Intra
SYMPK Q92797 CPSF2 Homo sapiens Q9P2I0
Anti Tag CoIP
18688255
Intra
SYMPK Q92797 CPSF2 Homo sapiens Q9P2I0
GMS
35177536
Intra
SYMPK Q92797 CPSF2 Homo sapiens Q9P2I0
Anti Tag CoIP
26496610
Intra
SYMPK Q92797 SSU72 Homo sapiens Q9NP77-1
X-Ray Diffraction
20861839
Intra
SYMPK Q92797 SSU72 Homo sapiens Q9NP77-1
GMS
20861839
Intra
SYMPK Q92797 CSTF2 Homo sapiens P33240
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14078 SYMPK Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SYMPK VGNC VGNC:47022
Felis catus SYMPK VGNC VGNC:65877
Bos taurus SYMPK VGNC VGNC:35514
Rattus norvegicus SYMPK RGD RGD:1306735
Macaca mulatta SYMPK VGNC VGNC:78195
Mus musculus SYMPK MGD MGI:1915438
Others SYMPK NCBI