HeE1-2Tyr
Based on 1 publication(s) in Google Scholar
HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 μM) activity in vitro.
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- Pureté: 96.68%
- CAS No.: 2245195-67-7
- Formule: C33H30N2O6S
- Masse moléculaire:582.67
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) HeE1-2Tyr
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Activité biologique
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RNA Polymerase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>100 μM
Compound: 1; PBTZ
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Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter Glo Luminescent assay
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter Glo Luminescent assay
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[PMID: 32435384] |
| Huh-7 | EC50 |
0.4 μM
Compound: 1; PBTZ
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Antiviral activity against Zika virus H/PF/2013 infected in human HuH7 cells assessed as reduction in virus replication incubated for 24 hrs by plaque reduction assay
Antiviral activity against Zika virus H/PF/2013 infected in human HuH7 cells assessed as reduction in virus replication incubated for 24 hrs by plaque reduction assay
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[PMID: 32435384] |
| Huh-7 | EC50 |
1.7 μM
Compound: 1; PBTZ
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Antiviral activity against Dengue virus 4 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
Antiviral activity against Dengue virus 4 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
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[PMID: 32435384] |
| Huh-7 | EC50 |
2.1 μM
Compound: 1; PBTZ
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Antiviral activity against Dengue virus 2 EDEN 3295 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
Antiviral activity against Dengue virus 2 EDEN 3295 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
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[PMID: 32435384] |
| Huh-7 | EC50 |
2.8 μM
Compound: 1; PBTZ
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Antiviral activity against Dengue virus 1 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
Antiviral activity against Dengue virus 1 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
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[PMID: 32435384] |
| Huh-7 | EC50 |
2.8 μM
Compound: 1; PBTZ
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Antiviral activity against Dengue virus 3 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
Antiviral activity against Dengue virus 3 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay
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[PMID: 32435384] |
| Vero C1008 | CC50 |
>100 μM
Compound: HeE1-2Tyr
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Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 37159959] |
| Vero C1008 | IC50 |
6.8 μM
Compound: 40
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Antiviral activity against DENV1 Djibouti infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis
Antiviral activity against DENV1 Djibouti infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis
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[PMID: 31128447] |
| Vero C1008 | IC50 |
6.8 μM
Compound: 40
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Antiviral activity against DENV2 Martinique infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis
Antiviral activity against DENV2 Martinique infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis
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[PMID: 31128447] |
| Vero C1008 | IC50 |
6.8 μM
Compound: 40
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Antiviral activity against DENV3 Bolivia infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis
Antiviral activity against DENV3 Bolivia infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis
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[PMID: 31128447] |
| Vero C1008 | IC50 |
6.8 μM
Compound: 40
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Antiviral activity against DENV4 Dakar infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis
Antiviral activity against DENV4 Dakar infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis
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[PMID: 31128447] |
HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC50 of 2.1 μM, as well as all the four Dengue virus (DENV) serotypes, with IC50 ranging from 6.8 to 15 μM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 μM[1].
Additionally, upon infection of human HEK 293 cells (CC50 of 50 μM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC50 values ranging from 3.9 to 12 μM[1].
HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2245195-67-7
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Appearance Solid
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Masse moléculaire 582.67
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Formule C33H30N2O6S
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Color White to yellow
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SMILES
OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC(C(C=C2C3=CC=CC=C3)=C4SC5=CC=C(OC6CCCCC6)C=C5N4C2=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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PLoS Pathog
TRIM14 restricts tembusu virus infection through degrading viral NS1 protein and activating type I interferon signaling. [Abstract]2025 May 28;21(5):e1013200. PMID: 40435148
Solvant et solubilité
DMSO : 100 mg/mL (171.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Delia Tarantino, et al. Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res. 2016 Oct;134:226-235. [Content Brief]
[2]. Milan Dejmek, et al. Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication. Viruses. 2021 Aug 11;13(8):1585. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7162 mL | 8.5812 mL | 17.1624 mL | 42.9059 mL |
| 5 mM | 0.3432 mL | 1.7162 mL | 3.4325 mL | 8.5812 mL | |
| 10 mM | 0.1716 mL | 0.8581 mL | 1.7162 mL | 4.2906 mL | |
| 15 mM | 0.1144 mL | 0.5721 mL | 1.1442 mL | 2.8604 mL | |
| 20 mM | 0.0858 mL | 0.4291 mL | 0.8581 mL | 2.1453 mL | |
| 25 mM | 0.0686 mL | 0.3432 mL | 0.6865 mL | 1.7162 mL | |
| 30 mM | 0.0572 mL | 0.2860 mL | 0.5721 mL | 1.4302 mL | |
| 40 mM | 0.0429 mL | 0.2145 mL | 0.4291 mL | 1.0726 mL | |
| 50 mM | 0.0343 mL | 0.1716 mL | 0.3432 mL | 0.8581 mL | |
| 60 mM | 0.0286 mL | 0.1430 mL | 0.2860 mL | 0.7151 mL | |
| 80 mM | 0.0215 mL | 0.1073 mL | 0.2145 mL | 0.5363 mL | |
| 100 mM | 0.0172 mL | 0.0858 mL | 0.1716 mL | 0.4291 mL |
HeE1-2Tyr Related Classifications
HY-100749 Related Classifications
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