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Cat. No.: HY-121372

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Lactandrate

Lactandrate is a D-high nitrogen steroid alkylating agent. It can interact with the ligand-binding domain (LBD) of estrogen receptor-alpha (ERα). Lactandrate has a growth inhibitory effect on breast cancer cells, with a GI₅₀ value ranging from 5 to 65 μM. It shows anti-tumor activity in mouse breast tumors (MXT and CD8F1) as well as in human xenograft MX-1.

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CAS No.: 43000-65-3
Formule: C₃₁H₄₄Cl₂N₂O₃
Masse moléculaire:563.60

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Lactandrate Chemical Structure

CAS No.: 43000-65-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Cellular Effect
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Estrogen Receptor/ERR :

Cellular Effect

Cell Line	Type	Value	Description	References
Hs 766	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 h by MTT assay Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 h by MTT assay	[PMID: 29649739]
Hs 766	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 by MTT assay Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 by MTT assay	[PMID: 29649739]
MCF7	GI₅₀	5 μM Compound: 104	Growth inhibition of human MCF7 cells after 48 h by MTT assay Growth inhibition of human MCF7 cells after 48 h by MTT assay	[PMID: 29649739]
MCF7	GI₅₀	5 μM Compound: 104	Growth inhibition of human MCF7 cells after 48 by MTT assay Growth inhibition of human MCF7 cells after 48 by MTT assay	[PMID: 29649739]
MIA PaCa-2	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 h by MTT assay Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 h by MTT assay	[PMID: 29649739]
MIA PaCa-2	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 by MTT assay Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 by MTT assay	[PMID: 29649739]
PANC-1	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 h by MTT assay Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 h by MTT assay	[PMID: 29649739]
PANC-1	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 by MTT assay Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 by MTT assay	[PMID: 29649739]
T47D	GI₅₀	5 μM Compound: 104	Growth inhibition of human T47D cells after 48 h by MTT assay Growth inhibition of human T47D cells after 48 h by MTT assay	[PMID: 29649739]
T47D	GI₅₀	5 μM Compound: 104	Growth inhibition of human T47D cells after 48 by MTT assay Growth inhibition of human T47D cells after 48 by MTT assay	[PMID: 29649739]

Chemical Information

CAS No. 43000-65-3
Masse moléculaire 563.60
Formule C₃₁H₄₄Cl₂N₂O₃
SMILES

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)OC(CC4=CC=C(C=C4)N(CCCl)CCCl)=O)([H])[C@@]5([H])[C@](CC3)(NC(CC5)=O)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Trafalis DT, et al. Lactandrate: a D-homo-aza-androsterone alkylator in the treatment of breast cancer. Breast Cancer Res Treat. 2006 May;97(1):17-31. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Lactandrate

Voir tous les produits spécifiques à Isoform Estrogen Receptor/ERR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Lactandrate Related Classifications

HY-121372 Related Classifications