Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents

  • Bioorg Med Chem Lett. 1998 Jun 2;8(11):1391-6. doi: 10.1016/s0960-894x(98)00232-7.
D Subrahmanyam  1 ,  B Renuka ,  C V Rao ,  P S Sagar ,  D S Deevi ,  J M Babu ,  K Vyas
Affiliations
  • 1. Natural Products Division, Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India.
PMID: 9871772 DOI: 10.1016/s0960-894x(98)00232-7
Abstract

Several D-ring modified analogues of podophyllotoxin were prepared viz semi-synthesis starting from naturally occurring podophyllotoxin and determined their in vitro anti-cancer activity. Most of the analogues have shown good activity towards human Cancer cell lines.