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Cat. No.: HY-189270

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Chitin synthase-IN-16

Chitin synthase-IN-16 is a competitive Chitin synthase 2 inhibitor with an IC₅₀ of 20.89 μM against CaChs2. Chitin synthase-IN-16 synergistically enhances the activity of Fluconazole (HY-B0101) against Fluconazole-tolerant Candida albicans. Chitin synthase-IN-16 can be used for research on invasive fungal infections.

For research use only. We do not sell to patients.

CAS No.: 702697-89-0
Formula: C₂₂H₂₅N₅O₄S₂
Molecular Weight:487.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Chitin synthase-IN-16 Chemical Structure

CAS No.: 702697-89-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

Chitin synthase-IN-16 (Compound Mol_1) (0.1-1000 μM; 2 h) inhibits the chitin synthase activity of CaChs2 in the crude enzyme preparation with an IC₅₀ of 20.89 μM^[1].
Chitin synthase-IN-16 alone (4-512 μM; 24 h) shows no significant antifungal activity against isolated Candida albicans strains (MIC > 512 μM)^[1].
Chitin synthase-IN-16 (64-128 μM; 24 h) exhibits strong synergistic antifungal activity with Fluconazole (HY-B0101) against isolated Candida albicans strains, with an FIC index of 0.16, reducing cell viability to below 5% when 128 μM Chitin synthase-IN-16 is combined with 32 μM FZ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 702697-89-0
Molecular Weight 487.60
Formula C₂₂H₂₅N₅O₄S₂
SMILES

O=S(N1CCOCC1)(C2=CC(/C(C(N3C)=O)=N/NC(NC4=CC=C(CC)C=C4)=S)=C3C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gao K, et al. Discovery and activity evaluation of fungal chitin synthase inhibitors via virtual screening. Bioorganic chemistry. 2026 Oct 05;181:110346.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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