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Cat. No.: HY-P12217

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Cyclic MC4R peptide agonist-1

Cyclic MC4R peptide agonist-1 is a cyclic peptide agonist of the melanocortin-4 receptor (melanocortin-4 receptor). Cyclic MC4R peptide agonist-1 activates the human melanocortin-4 receptor via an alternative activation motif centered on APWR, and this activation process is independent of the classical HFRW pharmacophore. Cyclic MC4R peptide agonist-1 inhibits signal transduction of the human melanocortin-3 receptor and melanocortin-5 receptor. Cyclic MC4R peptide agonist-1 is used in research related to obesity.

For research use only. We do not sell to patients.

Formula: C₉₄H₁₃₂N₂₆O₂₂
Molecular Weight:1978.21

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cyclic MC4R peptide agonist-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

MC4R

340 nM (EC₅₀)

MC3R

MC5R

All Melanocortin Receptor Isoforms :

In Vitro

Cyclic MC4R peptide agonist-1 (30 minutes) is a full hMC4R agonist with an EC₅₀ of 340 nM, requiring head-to-tail cyclization to retain hMC4R agonist activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1978.21
Formula C₉₄H₁₃₂N₂₆O₂₂
SMILES

O=C(N1[C@@H](CCC1)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CC4=CC=C(C=C4)O)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@H]7CC8=CC=CC=C8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)NC7=O
Sequence

cyclo(Ala-Pro-Trp-Arg-Glu-Ala-Tyr-Gly-Leu-Lys-Thr-Thr-Asn-Arg-Trp-Phe)
Sequence Shortening

cyclo(APWREAYGLKTTNRWF)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Møller V, Jet al. De novo designed cyclic MC4R peptide agonist reduces food intake in mice [Preprint]. bioRxiv. 2026 May 22. doi:10.64898/2026.05.19.721857.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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