CDK16-CCNY Protein, Human (Active, sf9, GST, Flag)

PCTAIRE1 protein, a versatile kinase, assumes a pivotal role in diverse cellular processes, particularly in vesicle-mediated transport and exocytosis. Its involvement extends to the regulation of GH1 release by brain neurons, underlining its significance in neuroendocrine functions. PCTAIRE1's reach encompasses the phosphorylation of NSF, modulating NSF oligomerization and thereby influencing crucial aspects of vesicle dynamics. Notably, it emerges as an essential player in spermatogenesis, contributing to normal reproductive processes. Additionally, PCTAIRE1 plays a key role in the intricate regulation of neuron differentiation and dendrite development, emphasizing its impact on neuronal morphology. Beyond its neuronal functions, PCTAIRE1 is implicated in the regulation of insulin secretion in response to changes in blood glucose levels, implicating its role in metabolic homeostasis. The kinase's ability to phosphorylate CCNY at 'Ser-336' in vitro further highlights its diverse molecular interactions and underscores its multifaceted role in cellular signaling.