2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. DCN1-UBC12-IN-2

DCN1-UBC12-IN-2 is a potent and specific DCN1-UBC12 inhibitor (IC50=9.55 nM). DCN1-UBC12-IN-2 could specifically target DCN1-UBC12 interaction and relieve Ang II-induced cardiac fibroblast activation.

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DCN1-UBC12-IN-2

DCN1-UBC12-IN-2 Estructura química

No. CAS : 2374827-47-9

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DCN1-UBC12-IN-2 Related Antibodies

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Descripciòn

DCN1-UBC12-IN-2 is a potent and specific DCN1-UBC12 inhibitor (IC50=9.55 nM). DCN1-UBC12-IN-2 could specifically target DCN1-UBC12 interaction and relieve Ang II-induced cardiac fibroblast activation[1].

Cellular Effect
Cell Line Type Value Description References
Fibroblast of cardiac tissue IC50
27.34 nM
Compound: 39; DN-2
Cytotoxicity against Sprague-Dawley rat cardiac fibroblast incubated for 24 hrs by MTT assay
Cytotoxicity against Sprague-Dawley rat cardiac fibroblast incubated for 24 hrs by MTT assay
[PMID: 34939411]
Fibroblast of cardiac tissue IC50
27.34 μM
Compound: 39; DN-2
Cytotoxicity against Sprague-Dawley rat cardiac fibroblast by MTT assay
Cytotoxicity against Sprague-Dawley rat cardiac fibroblast by MTT assay
[PMID: 34939411]
In Vitro

DCN1-UBC12-IN-2 (DN-2) possesses relatively low cytotoxicity toward cardiac fibroblasts (CFs) with an IC50 of 27.34 μM for 24 h.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DCN1-UBC12-IN-2 Related Antibodies
Peso molecular

542.03

Fòrmula

C23H20ClN7O3S2
No. CAS
SMILES

N#CC1=C(C2=CC(OC)=C(OC)C(OC)=C2)N=C(SCC3=CC=C(Cl)C=C3)N=C1SC4=NN=NN4C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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DCN1-UBC12-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCN1-UBC12-IN-22374827-47-9E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseanticardiac fibrotic effectselectivelow cytotoxicityDCN1-UBC12 interactionInhibitorinhibitorinhibit

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Nombre del producto:
DCN1-UBC12-IN-2
Cat. No.:
HY-142694
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MCE Japan Authorized Agent:

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