(RS)-MCPG
Based on 1 publication(s) in Google Scholar
(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons.
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- Reinheit: 99.05%
- CAS. Nr.: 146669-29-6
- Formel: C10H11NO4
- Molecular Weight:209.20
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Publications Citing Use of MedChemExpress (MCE) (RS)-MCPG
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Biologische Aktivität
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mGluR |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
700 μM
Compound: 3b
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Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.
Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.
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10.1016/0960-894X(96)00104-7 |
Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 146669-29-6
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Appearance Solid
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Molecular Weight 209.20
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Formel C10H11NO4
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Color White to off-white
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SMILES
CC(C(O)=O)(N)C1=CC=C(C(O)=O)C=C1
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Synonyms
alpha-MCPG
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Front Cell Neurosci
Pin1 Is Regulated by CaMKII Activation in Glutamate-Induced Retinal Neuronal Regulated Necrosis. [Abstract]2019 Jun 25:13:276. PMID: 31293391
Lösungsmittel & Löslichkeit
1M NaOH : 100 mg/mL (478.01 mM; ultrasonic and adjust pH to 10 with NaOH)
DMSO : 6 mg/mL (28.68 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 1M NaOH | 1 mM | 4.7801 mL | 23.9006 mL | 47.8011 mL | 119.5029 mL |
| 5 mM | 0.9560 mL | 4.7801 mL | 9.5602 mL | 23.9006 mL | |
| 10 mM | 0.4780 mL | 2.3901 mL | 4.7801 mL | 11.9503 mL | |
| 15 mM | 0.3187 mL | 1.5934 mL | 3.1867 mL | 7.9669 mL | |
| 20 mM | 0.2390 mL | 1.1950 mL | 2.3901 mL | 5.9751 mL | |
| 25 mM | 0.1912 mL | 0.9560 mL | 1.9120 mL | 4.7801 mL | |
| 1M NaOH | 30 mM | 0.1593 mL | 0.7967 mL | 1.5934 mL | 3.9834 mL |
| 40 mM | 0.1195 mL | 0.5975 mL | 1.1950 mL | 2.9876 mL | |
| 50 mM | 0.0956 mL | 0.4780 mL | 0.9560 mL | 2.3901 mL | |
| 60 mM | 0.0797 mL | 0.3983 mL | 0.7967 mL | 1.9917 mL | |
| 80 mM | 0.0598 mL | 0.2988 mL | 0.5975 mL | 1.4938 mL | |
| 100 mM | 0.0478 mL | 0.2390 mL | 0.4780 mL | 1.1950 mL |
(RS)-MCPG Related Classifications
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