Monomeric and Dimeric Cytotoxic Guaianolide-Type Sesquiterpenoids from the Aerial Parts of Chrysanthemum indicum

  • J Nat Prod. 2019 Feb 22;82(2):349-357. doi: 10.1021/acs.jnatprod.8b00863.
Pan Luo  1 ,  Yanfang Cheng  1 ,  Zhiyong Yin  1 ,  Chanjuan Li  1 ,  Jun Xu  1  2 ,  Qiong Gu  1  2
Affiliations
  • 1. Research Center for Drug Discovery, School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , People's Republic of China.
  • 2. Guangdong Provincial Key Laboratory of New Drug Design and Evaluation , Guangzhou 510006 , People's Republic of China.
PMID: 30726671 DOI: 10.1021/acs.jnatprod.8b00863
Abstract

Twelve new guaianolide-type sesquiterpenoids (1-12) and five known guaianolide derivatives (13-17) were isolated from an aqueous ethanol extract of the aerial parts of Chrysanthemum indicum. Their structures were determined through spectroscopic data analysis. The absolute configurations of the new compounds were assigned by X-ray crystallography and electronic circular dichroism. Compound 5 shows multiple cytotoxic activities against four human naso-pharyngeal carcinoma (NPC) cell lines (CNE1, CNE2, SUNE-1, and HONE-1) and one human intestinal epithelial cell line (HT-29) with IC50 values of 4.6, 6.0, 3.5, 4.3, and 9.6 μM, respectively. Compound 16 exhibits weak cytotoxicity against four NPC cell lines, CNE1 (IC50 = 7.3 μM), CNE2 (IC50 = 7.4 μM), HONE-1 (IC50 = 7.6 μM), and SUNE-1 (IC50 = 5.6 μM), but no cytotoxicity against HT-29 (IC50 > 10 μM).