Bcar1 - breast cancer anti-estrogen resistance 1 Gene

Also Known as Cas; Crkas

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12927

Summary

Predicted to enable protein domain specific binding activity and protein kinase binding activity. Involved in G protein-coupled receptor signaling pathway and platelet-derived growth factor receptor signaling pathway. Acts upstream of or within cell migration. Located in several cellular components, including actin cytoskeleton; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member). [provided by Alliance of Genome Resources, Apr 2022]

Bcar1 Products (2)

mRNA Protein Name
NM_001198839.1 NP_001185768.1 breast cancer anti-estrogen resistance protein 1 isoform A
NM_009954.3 NP_034084.2 breast cancer anti-estrogen resistance protein 1 isoform B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7479864 MGI
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9083073 MGI
acts upstream of or within cell migration IDA
IDA: Inferred from direct assay
15728191 MGI
involved in platelet-derived growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
9083073 MGI
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
11864995 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
15728191 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
15728191 MGI
located in membrane IMP
IMP: Inferred from mutant phenotype
22801373 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

breast cancer anti-estrogen resistance protein 1

  • CRK-associated substrate

  • p130 Cas

  • p130cas

  • v-crk-associated tyrosine kinase substrate

Bcar1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Bcar1 Q61140 Ptk2 Mus musculus P34152
Anti Bait CoIP
18233957
Intra
Bcar1 Q61140 Nphp1 Mus musculus Q9QY53
Y2H
10739664
Intra
Bcar1 Q61140 Srcin1 Mus musculus Q9QWI6
Pull Down
14657239
Cross
Bcar1 Q61140 PTPN1 Homo sapiens P18031
Phosphatase Assay
9418872
Cross
Bcar1 Q61140 PTPN1 Homo sapiens P18031
Pull Down
12023880
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01397 BCAR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcar1 NCBI NCBI:9564