PIN1-IN-7
PIN1-IN-8 is a covalent inhibitor of Pin1, with IC50 values of 4.19 μM and 1.54 μM against purified Pin1 and Pin1 enzymatic activity, respectively. PIN1-IN-7 exerts antiproliferative effects and induces apoptosis by downregulating c-Myc and Cyclin D1. PIN1-IN-7 can be used in the research of triple-negative breast cancer.
For research use only. We do not sell to patients.
- Formula: C18H19NO5S2
- Molecular Weight:393.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PIN1-IN-7 (Compound T7) inhibits the proliferation of MDA-MB-231 and HCT116 cancer cells after 96 h, with IC50 values of 14.35 μM and 13.80 μM, respectively[1].
PIN1-IN-7 (96-120 h) inhibits the proliferation of breast cancer cell lines, with IC50 values of 14.35 μM and 6.89 μM against MDA-MB-231 and MDA-MB-468, respectively[1].
PIN1-IN-7 (14 days) potently inhibits the colony-forming ability of MDA-MB-231 and HCT116 cancer cells, with IC50 values of 1.14 μM and 3.36 μM, respectively[1].
PIN1-IN-7 (2-8 μM; 24-72 h) induces apoptosis and G0/G1 phase arrest in MDA-MB-468 cells, and inhibits cell migration[1].
PIN1-IN-7 (12-48 h) reduces Pin1 substrates, inhibits oncoproteins such as c-Myc and cyclin D1, and upregulates the cleavage of the apoptotic signaling protein PARP1 in MDA-MB-468 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-468 cells
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Concentration:2, 4 and 8 μM
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Incubation Time:72 h
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Result:Induced early apoptosis increased from 0.98% to 39.70%.
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Cell Line:MDA-MB-468 cells
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Concentration:2, 4 and 8 μM
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Incubation Time:48 h
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Result:Induced the cells to shift from the G0/G1 phase by 62.02% to 67.18%.
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Cell Line:MDA-MB-468 cells
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Concentration:2, 4 and 8 μM
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Incubation Time:24 h
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Result:Exhibited dose-dependent inhibition of cell migration.
Chemical Information
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Molecular Weight 393.48
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Formula C18H19NO5S2
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SMILES
O=C(N(C1CS(CC1)(=O)=O)CC2=CC3=C(S2)C=CC=C3)/C=C/C(OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PIN1-IN-7 Related Classifications
HY-184932 Related Classifications
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