2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. Dihydrocapsiate

Dihydrocapsiate, as a compound of capsinoid family, is an orally active TRPV1 agonist. Dihydrocapsiate can be used for the research of metabolism disease.

For research use only. We do not sell to patients.

Dihydrocapsiate Chemical Structure

Dihydrocapsiate Chemical Structure

CAS No. : 205687-03-2

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Dihydrocapsiate Related Antibodies

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Description

Dihydrocapsiate, as a compound of capsinoid family, is an orally active TRPV1 agonist. Dihydrocapsiate can be used for the research of metabolism disease[1].

IC50 & Target[1]

TRPV1

 

In Vitro

Dihydrocapsiate (10, 25 and 50 μM; 48 hours; human preadipocytes) does not affect cell viability[1].
Dihydrocapsiate (10 and 20 μM; 8 days; mature adipocytes) markedly decreases the expression levels of other adipogenic markers (such as SREBP1, FABP4, PLIN1, ADIPOQ and LEPTIN) and inflammatory markers (MCP1 and TNFα), whereas it enhances the expression levels of PGC1α (master regulator of mitochondrial biogenesis) and TBX1 (marker of “brite” cell) [1].
Dihydrocapsiate (25~200 μM; RAW 264.7 cells) prevents NO release and intracellular ROS generation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dihydrocapsiate Related Antibodies

Cell Viability Assay[1]

Cell Line: Human preadipocytes
Concentration: 10, 25 and 50 μM
Incubation Time: 48 hours
Result: Did not affect cell viability.

RT-PCR[1]

Cell Line: Mature adipocytes
Concentration: 10 and 20 μM
Incubation Time: 8 days
Result: Markedly decreased the expression levels of other adipogenic markers (such as SREBP1, FABP4, PLIN1, ADIPOQ and LEPTIN) and inflammatory markers (MCP1 and TNFα), whereas it enhanced the expression levels of PGC1α (master regulator of mitochondrial biogenesis) and TBX1 (marker of “brite” cell).
In Vivo

Dihydrocapsiate (2 and 10 mg/kg; p.o.) improves morphometric parameters and insulin levels, prevents high fat diet (HFD)-induced adipocyte size and enhances energy expenditure-related genes in WAT, alleviates HFD-induced hepatic steatosis, prevents HFD-induced fat deposition and enhances mitochondrial biogenesis genes in BAT and improves intestinal morphology and modulates SCFA availability.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD-fed mice[1]
Dosage: 2 and 10 mg/kg
Administration: P.o.
Result: Improved morphometric parameters and insulin levels, prevented HFD-induced adipocyte size and enhanced energy expenditure-related genes in WAT, alleviated HFD-induced hepatic steatosis, prevented HFD-induced fat deposition and enhanced mitochondrial biogenesis genes in BAT and improved intestinal morphology and modulates SCFA availability.
Clinical Trial
Molecular Weight

308.41

Formula

C18H28O4
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC(C)CCCCCCC(OCC1=CC=C(O)C(OC)=C1)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 99.18%

COA (241 KB) HNMR (200 KB) LCMS (158 KB)

Handling Instructions (2659 KB)
References
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Dihydrocapsiate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihydrocapsiate205687-03-2TRP ChannelTransient receptor potential channelscapsinoidorallyactivemetabolismobesityInhibitorinhibitorinhibit

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