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Cat. No.: HY-N8674

Dihydroisotanshinone II

Dihydroisotanshinone II is a Diterpenoids product that can be isolated from the roots of Salvia miltiorrhiza.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CAS No.: 260397-58-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Dihydroisotanshinone II is a Diterpenoids product that can be isolated from the roots of Salvia miltiorrhiza^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
AGS	IC₅₀	>20 μM Compound: 8, dihydroisotanshinone ii	Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay	[PMID: 17583950]
AGS	IC₅₀	>50 μM Compound: 8, dihydroisotanshinone ii	Viability of human AGS cells under normoxic conditions after 24 hrs by MTT assay Viability of human AGS cells under normoxic conditions after 24 hrs by MTT assay	[PMID: 17583950]
Hep 3B2	IC₅₀	>20 μM Compound: 8, dihydroisotanshinone ii	Inhibition of HIF1 activation in human Hep3B cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay Inhibition of HIF1 activation in human Hep3B cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay	[PMID: 17583950]
Hep 3B2	IC₅₀	>50 μM Compound: 8, dihydroisotanshinone ii	Viability of human Hep3B cells under normoxic conditions after 24 hrs by MTT assay Viability of human Hep3B cells under normoxic conditions after 24 hrs by MTT assay	[PMID: 17583950]

CAS No. 260397-58-8
Molecular Weight 278.30
Formula C₁₈H₁₄O₃
SMILES

O=C1C2=C(C3=CC=CC(C)=C3C=C2)C4=C([C@@H](CO4)C)C1=O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Plants
- Labiatae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.